SCHEMBL4420194

SCHEMBL4420194

Cc1ccc(-c2ccc(-c3csc(NC(=O)CBr)n3)cc2)cc1

nearest known ligand 0.65

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.65
HDAC9 Q9UKV0 1/20 0.65
GSTO1 P78417 1/20 0.62
NPC1 O15118 3/20 0.62
ALDH1A1 P00352 3/20 0.62
NPSR1 Q6W5P4 2/20 0.62
SMN1; SMN2 Q16637 2/20 0.62
TP53 P04637 1/20 0.62
L3MBTL1 Q9Y468 1/20 0.62
MAPT P10636 5/20 0.61
KMT2A Q03164 3/20 0.61
GAA P10253 3/20 0.61
MEN1 O00255 2/20 0.59
RAB9A P51151 3/20 0.58
KDM4E B2RXH2 3/20 0.58
LMNA P02545 2/20 0.58
CASP3 P42574 1/20 0.58
SENP7 Q9BQF6 1/20 0.58
ACHE P22303 1/20 0.58
WNT3A P56704 1/20 0.57

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4410636 0.86 MAPT (0.70) GSTO1NPC1ALDH1A1SMN1; SMN2MAPT
SCHEMBL4408570 0.86 GAA (0.61) HDAC1HDAC9NPC1ALDH1A1NPSR1
SCHEMBL14085825 0.86 HDAC1 (0.67) HDAC1HDAC9GSTO1NPC1ALDH1A1
SCHEMBL4551855 0.86 LMNA (0.56) HDAC1HDAC9GSTO1NPC1ALDH1A1
SCHEMBL4416778 0.85 RAB9A (0.63) NPC1SMN1; SMN2MAPTKMT2AMEN1
SCHEMBL480758 0.85 MAPT (0.71) GSTO1NPC1ALDH1A1SMN1; SMN2MAPT
SCHEMBL21586296 0.85 KMT2A (0.74) HDAC1HDAC9ALDH1A1SMN1; SMN2MAPT
SCHEMBL21226526 0.85 HDAC1 (0.66) HDAC1HDAC9GSTO1NPC1ALDH1A1
SCHEMBL28643881 0.85 HDAC1 (0.66) HDAC1HDAC9GSTO1NPC1ALDH1A1
SCHEMBL7929906 0.85 HDAC1 (0.73) HDAC1HDAC9GSTO1NPC1ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009144548-A1 IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS GLENMARK PHARMACEUTICALS S.A. (CH) 2009-12-03 WO disclosed
WO-2009144548-A1 IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS GLENMARK PHARMACEUTICALS S.A. (CH) 2009-12-03 WO disclosed