Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.63 |
| ▸ | NPC1 | O15118 | 4/20 | 0.63 |
| ▸ | MAPT | P10636 | 4/20 | 0.63 |
| ▸ | PKM | P14618 | 1/20 | 0.63 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.60 |
| ▸ | LMNA | P02545 | 3/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.60 |
| ▸ | WNT3A | P56704 | 1/20 | 0.60 |
| ▸ | CASP3 | P42574 | 2/20 | 0.57 |
| ▸ | SENP7 | Q9BQF6 | 2/20 | 0.57 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.57 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.57 |
| ▸ | MEN1 | O00255 | 2/20 | 0.56 |
| ▸ | ELOVL1 | Q9BW60 | 1/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.55 |
| ▸ | RORC | P51449 | 2/20 | 0.55 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.54 |
| ▸ | RECQL | P46063 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13570200 | 0.88 | KMT2A (0.60) | RAB9ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL4409450 | 0.87 | KMT2A (0.59) | RAB9ANPC1MAPTPKMSMN1; SMN2 | |
| SCHEMBL4410618 | 0.86 | MAPT (0.58) | RAB9ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL4414463 | 0.86 | TRPA1 (0.59) | RAB9ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL4420194 | 0.85 | HDAC1 (0.65) | RAB9ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL2093712 | 0.85 | ABL1 (0.70) | RAB9ANPC1MAPTPKMSMN1; SMN2 | |
| SCHEMBL4408570 | 0.85 | GAA (0.61) | RAB9ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL21586296 | 0.84 | KMT2A (0.74) | RAB9AMAPTSMN1; SMN2LMNAKMT2A | |
| SCHEMBL480758 | 0.84 | MAPT (0.71) | RAB9ANPC1MAPTSMN1; SMN2LMNA | |
| SCHEMBL2452315 | 0.83 | ELOVL1 (0.72) | RAB9ANPC1MAPTPKMSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |
| WO-2009144548-A1 | IMIDAZO [2,1-B] PURINE DERIVATIVES AS TRPA1 MODULATORS | GLENMARK PHARMACEUTICALS S.A. (CH) | 2009-12-03 | — | — | WO | disclosed |