Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP11B2 | P19099 | 11/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 8/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.37 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | HTR6 | P50406 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.35 |
| ▸ | NOS2 | P35228 | 1/20 | 0.34 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | JAK2 | O60674 | 1/20 | 0.33 |
| ▸ | JAK1 | P23458 | 1/20 | 0.33 |
| ▸ | TYK2 | P29597 | 1/20 | 0.33 |
| ▸ | JAK3 | P52333 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410334 | 0.90 | CYP11B2 (0.38) | CYP11B2CYP11B1PTGER4JAK2JAK1 | |
| SCHEMBL2957615 | 0.86 | CYP11B2 (0.45) | CYP11B2CYP11B1MEN1KMT2ANOS2 | |
| SCHEMBL1666145 | 0.81 | S1PR1 (0.38) | CYP11B2PTGER4 | |
| SCHEMBL664094 | 0.81 | PTGER4 (0.34) | CYP11B2CYP11B1PTGER4JAK2JAK1 | |
| SCHEMBL661430 | 0.81 | CNR2 (0.40) | — | |
| SCHEMBL662370 | 0.80 | PTGER4 (0.32) | CYP11B2CYP11B1PTGER4 | |
| SCHEMBL661470 | 0.80 | RORC (0.39) | MAPTJAK2JAK1TYK2JAK3 | |
| SCHEMBL663298 | 0.79 | TLR7 (0.39) | — | |
| SCHEMBL27673238 | 0.79 | CNR2 (0.42) | CYP11B2NOS2 | |
| SCHEMBL4408059 | 0.79 | P2RX3 (0.40) | MEN1KMT2AJAK2JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2050736-A1 | Imidazole derivatives, processes for preparing them and their uses | UCB Pharma, S.A. (BE) | 2009-04-22 | — | — | EP | disclosed |