SCHEMBL440926

SCHEMBL440926

Nc1ncnc2c1nc(Br)n2[C@@H]1O[C@H](CO)C(O)C1O

nearest known ligand 0.79

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
NADK O95544 2/20 0.79
HSPA8 P11142 3/20 0.78
HSPA5 P11021 2/20 0.78
RXFP1 Q9HBX9 1/20 0.71
GAPDH P04406 3/20 0.68
HSD17B10 Q99714 1/20 0.68
SMN1; SMN2 Q16637 2/20 0.67
LMNA P02545 1/20 0.67
TP53 P04637 1/20 0.67
HBB P68871 1/20 0.67
ADORA3 P0DMS8 3/20 0.63
SLC28A2 O43868 2/20 0.62
DPP4 P27487 1/20 0.62
MEN1 O00255 1/20 0.62
SLC28A1 O00337 1/20 0.62
MAP3K7 O43318 1/20 0.62
MAPK1 P28482 1/20 0.62
ADORA2A P29274 1/20 0.62
ADORA2B P29275 1/20 0.62
ADORA1 P30542 1/20 0.62

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12030991 1.00 NADK (0.79) NADKHSPA8HSPA5RXFP1GAPDH
SCHEMBL20419274 1.00 NADK (0.79) NADKHSPA8HSPA5RXFP1GAPDH
SCHEMBL6671819 1.00 NADK (0.79) NADKHSPA8HSPA5RXFP1GAPDH
SCHEMBL14435669 1.00 NADK (0.79) NADKHSPA8HSPA5RXFP1GAPDH
SCHEMBL13587343 1.00 NADK (0.79) NADKHSPA8HSPA5RXFP1GAPDH
SCHEMBL440925 1.00 NADK (0.79) NADKHSPA8HSPA5RXFP1GAPDH
SCHEMBL1106674 1.00 NADK (0.79) NADKHSPA8HSPA5RXFP1GAPDH
SCHEMBL29707221 0.99 NADK (0.78) NADKHSPA8HSPA5RXFP1GAPDH
SCHEMBL28823544 0.99 NADK (0.78) NADKHSPA8HSPA5RXFP1GAPDH
Phosphoric Acid SCHEMBL8628967 0.94 NADK (0.72) NADKHSPA8HSPA5RXFP1GAPDH

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1452 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250304916-A1 METHODS AND COMPOSITIONS FOR GENERATING VASCULAR LEPTOMENINGEAL CELLS TRAILHEAD BIOSYSTEMS INC (US) 2025-10-02 US claimed
CN-117402814-A Endothelial induction culture medium and method for inducing differentiation of pluripotent stem cells into vascular endothelial cells 北京朴汇细胞生物科技有限公司 2024-01-16 CN claimed
US-20230332103-A1 Methods and Compositions for Generating Human Forebrain Neural Progenitor Cells and for Maturation Thereof to Parvalbumin+ Interneurons TRAILHEAD BIOSYSTEMS INC. 2023-10-19 US claimed
WO-2023075913-A1 METHODS AND COMPOSITIONS FOR GENERATING HUMAN FOREBRAIN NEURAL PROGENITOR CELLS AND FOR MATURATION THEREOF TO PARVALBUMIN+ INTERNEURONS TRAILHEAD BIOSYSTEMS INC. (US) 2023-05-04 WO claimed
US-20220349874-A1 METHODS OF GENERATING HUMAN ENDOMETRIAL STROMAL FIBROBLASTS AND THREE-DIMENSIONAL MULTI-LAYERED HUMAN ENDOMETRIAL TISSUE COMPOSITIONS NORTHWESTERN UNIVERSITY 2022-11-03 US claimed
US-20220002737-A1 ARTIFICIAL NUCLEIC ACID MOLECULES FOR IMPROVED PROTEIN EXPRESSION CUREVAC AG (DE) 2022-01-06 US claimed
CN-112079883-A Production process of vidarabine 兰州欣立医药科技有限责任公司 2020-12-15 CN claimed
EP-2877855-B1 MULTISIGNAL REAGENTS FOR LABELING ANALYTES ENZO LIFE SCIENCES INC (US) 2020-04-15 EP claimed
WO-2020028134-A1 METHODS AND COMPOSITIONS FOR TREATING CANCER FRED HUTCHINSON CANCER RESEARCH CENTER (US) 2020-02-06 WO claimed
US-20190285621-A1 MULTISIGNAL REAGENTS FOR LABELING ANALYTES ENZO LIFE SCIENCE, INC. (US) 2019-09-19 US claimed
US-20040110718-A1 Anti-HCV nucleoside derivatives DEVOS RENE (GB) 2004-06-10 US claimed
WO-2004035083-A2 COMPOSITIONS FOR THE TREATMENT OF AUTOIMMUNE DISORDERS MEDICAL RESEARCH COUNCIL (GB) 2004-04-29 WO claimed
WO-2003104482-A1 SIGNALS AND MOLECULAR SPECIES INVOLVED IN SENESCENCE METABOLIC ENGINEERING LABORATORIES CO., LTD. (KR) 2003-12-18 WO claimed
US-6512004-B2 Activation of kinase THE REGENTS OF THE UNIVERSITY OF CALIFORNIA 2003-01-28 US claimed
US-20030008841-A1 Anti-HCV nucleoside derivatives F. HOFFMAN-LA ROCHE, A SWISS COMPANY (CH) 2003-01-09 US claimed
US-20020142990-A1 Promoters of neural regeneration NIH-DEITR 2002-10-03 US claimed
WO-2002057425-A2 NUCLEOSIDE DERIVATIVES AS INHIBITORS OF RNA-DEPENDENT RNA VIRAL POLYMERASE MERCK & CO., INC. (US) 2002-07-25 WO claimed
US-20020006916-A1 Activation of kinase NIH-DEITR 2002-01-17 US claimed
US-6284539-B1 IDENTIFYING CELLS EXPRESSING TYROSINE HYDROXYLASE; INCUBATING STEM CELLS WITH POLYNUCLEOTIDE ENCODING TRANSCRIPTION REGULATOR; PARKINSON'S DISEASE; DOPAMINERGIC CELL FATE NEURALSTEM BIOPHARMACEUTICALS, LTD. 2001-09-04 US claimed
EP-0066918-A1 Anti-inflammatory compositions exhibiting minimized gastric damage THE PROCTER & GAMBLE COMPANY (US) 1982-12-15 EP claimed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20030008841-A1 Anti-HCV nucleoside derivatives PNP, HAVCR2, NUDT14 NADK 134/4885HSPA8 1847/4885HSPA5 1928/4885
US-20040110718-A1 Anti-HCV nucleoside derivatives PNP, HAVCR2, NUDT14 NADK 134/4885HSPA8 1847/4885HSPA5 1928/4885
US-20220002737-A1 ARTIFICIAL NUCLEIC ACID MOLECULES FOR IMPROVED PROTEIN EXPRESSION CPSF6, CPSF1, RNMT NADK 1380/4885HSPA8 1329/4885HSPA5 681/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.