SCHEMBL440951

SCHEMBL440951

N[C@H](C=O)Cc1c[nH]c2cc[c]cc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTR2A P28223 9/20 0.40
HTR2C P28335 5/20 0.40
HTR1A P08908 4/20 0.40
HTR2B P41595 4/20 0.40
SLC6A4 P31645 2/20 0.40
HTR7 P34969 2/20 0.40
HTR1D P28221 2/20 0.40
HTR1B P28222 2/20 0.40
ADRB1 P08588 1/20 0.40
ADRA2A P08913 1/20 0.40
SLC6A2 P23975 1/20 0.40
HTR1E P28566 1/20 0.40
HTR6 P50406 1/20 0.40
SLC6A3 Q01959 1/20 0.40
BLM P54132 3/20 0.40
KDM4E B2RXH2 2/20 0.40
LMNA P02545 2/20 0.40
MAPT P10636 2/20 0.40
TSHR P16473 2/20 0.40
PMP22 Q01453 2/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2198661 0.79 HTR2A (0.64) HTR2AHTR2CHTR1AHTR2BSLC6A4
SCHEMBL10650990 0.79 HTR2A (0.64) HTR2AHTR2CHTR1AHTR2BSLC6A4
SCHEMBL7029247 0.79 HTR2A (0.64) HTR2AHTR2CHTR1AHTR2BSLC6A4
SCHEMBL7653075 0.77 HTR2A (0.45) HTR2AHTR2CHTR1AHTR2BSLC6A4
SCHEMBL1337678 0.75 HTR1A (0.38) HTR2AHTR2CHTR1AHTR2BSLC6A4
SCHEMBL7429865 0.74 GPR84 (0.58) HTR2AHTR2CHTR1AHTR2BSLC6A4
SCHEMBL19047013 0.74 HTR2C (0.68) HTR2AHTR2CHTR1AHTR2BSLC6A4
SCHEMBL22796513 0.74 HTR2A (0.56) HTR2AHTR2CHTR1AHTR2BSLC6A4
SCHEMBL4373291 0.74 HTR2A (0.68) HTR2AHTR2CHTR1AHTR2BSLC6A4
SCHEMBL7439210 0.74 HTR2A (0.68) HTR2AHTR2CHTR1ASLC6A4TSHR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 20 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2011071541-A2 CADHERIN MODULATORY AGENTS THE SCRIPPS RESEARCH INSTITUTE (US) 2011-06-16 WO claimed
US-9943577-B2 Aminoacyl tRNA synthetases for modulating inflammation ATYR PHARMA, INC. (US) 2018-04-17 US disclosed
EP-2939689-B1 Glutaminyl tRNA synthetases for use in the treatment of inflammatory disorders ATYR PHARMA INC (US) 2017-09-13 EP disclosed
US-20170202933-A1 AMINOACYL TRNA SYNTHETASES FOR MODULATING INFLAMMATION ATYR PHARMA, INC. 2017-07-20 US disclosed
US-9540628-B2 Aminoacyl tRNA synthetases for modulating inflammation ATYR PHARMA, INC. (US) 2017-01-10 US disclosed
US-9328340-B2 Amino acyl tRNA synthetases for modulating inflammation ATYR PHARMA, INC. (US) 2016-05-03 US disclosed
EP-2939689-A1 Glutaminyl tRNA synthetases for modulating inflammation Atyr Pharma, Inc. (US) 2015-11-04 EP disclosed
US-9127268-B2 Aminoacyl tRNA synthetases for modulating inflammation ATYR PHARMA, INC. (US) 2015-09-08 US disclosed
US-20150140072-A1 AMINOACYL TRNA SYNTHETASES FOR MODULATING INFLAMMATION ATYR PHARMA, INC. 2015-05-21 US disclosed
US-20150132277-A1 Monomeric Forms of Human Aminoacyl-tRNA Synthetases Having Non-Canonical Biological Activities SCRIPPS RESEARCH INST (US) 2015-05-14 US disclosed
EP-2509625-B1 HISTIDYL TRNA SYNTHETASES FOR REDUCING INFLAMMATION ATYR PHARMA INC (US) 2015-01-28 EP disclosed
US-8828395-B2 Antibodies that bind tyrosyl-tRNA synthetases ATYR PHARMA, INC. (US) 2014-09-09 US disclosed
US-8828685-B2 Monomeric forms of human aminoacyl-t-RNA synthetases having non-canonical biological activities THE SCRIPPS RESEARCH INSTITUTE (US) 2014-09-09 US disclosed
US-20130273045-A1 AMINO ACYL TRNA SYNTHETASES FOR MODULATING INFLAMMATION ATYR PHARMA, INC. 2013-10-17 US disclosed
US-20130108630-A1 AMINO ACYL TRNA SYNTHETASES FOR MODULATING INFLAMMATION ATYR PHARMA, INC. 2013-05-02 US disclosed
US-20130052177-A1 MONOMERIC FORMS OF HUMAN AMINOACYL-t-RNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES THE SCRIPPS RESEARCH INSTITUTE (US) 2013-02-28 US disclosed
US-20120064082-A1 AMINOACYL TRNA SYNTHETASES FOR MODULATING HEMATOPOIESIS ATYR PHARMA, INC. (US) 2012-03-15 US disclosed
WO-2011097031-A2 MONOMERIC FORMS OF HUMAN AMINOACYL-TRNA SYNTHETASES HAVING NON-CANONICAL BIOLOGICAL ACTIVITIES THE SCRIPPS RESEARCH INSTITUTE (US) 2011-08-11 WO disclosed
US-20110150885-A1 AMINOACYL TRNA SYNTHETASES FOR MODULATING HEMATOPOIESIS ATYR PHARMA, INC. (US) 2011-06-23 US disclosed
WO-2011071541-A2 CADHERIN MODULATORY AGENTS THE SCRIPPS RESEARCH INSTITUTE (US) 2011-06-16 WO disclosed