Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | MAPT | P10636 | 5/20 | 0.47 |
| ▸ | HTT | P42858 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 2/20 | 0.39 |
| ▸ | PKM | P14618 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14534466 | 0.92 | MAPK14 (0.45) | ALDH1A1SMN1; SMN2MAPTHTTNPSR1 | |
| SCHEMBL14534469 | 0.90 | MAPK14 (0.43) | ALDH1A1SMN1; SMN2MAPTHTTNPSR1 | |
| SCHEMBL4565964 | 0.88 | MAPK14 (0.42) | ALDH1A1SMN1; SMN2MAPTHTTNPSR1 | |
| SCHEMBL4417851 | 0.87 | MAPK14 (0.44) | ALDH1A1SMN1; SMN2MAPTHTTNPSR1 | |
| SCHEMBL4413435 | 0.82 | MAPK14 (0.47) | ALDH1A1SMN1; SMN2MAPTMAPK14RAB9A | |
| SCHEMBL14534686 | 0.82 | MAPK14 (0.47) | ALDH1A1SMN1; SMN2MAPTMAPK14CYP2C9 | |
| SCHEMBL4410752 | 0.81 | NPC1 (0.46) | ALDH1A1SMN1; SMN2MAPTMAPK14LRRK2 | |
| SCHEMBL4417839 | 0.80 | MAPK14 (0.45) | ALDH1A1SMN1; SMN2MAPTMAPK14RAB9A | |
| SCHEMBL5489718 | 0.80 | NR3C1 (0.51) | SMN1; SMN2MAPK14RAB9ANPC1 | |
| SCHEMBL4410224 | 0.80 | MAPK14 (0.43) | ALDH1A1SMN1; SMN2MAPTMAPK14LRRK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |