Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 5/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 4/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.41 |
| ▸ | MAPT | P10636 | 4/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.40 |
| ▸ | SIRT1 | Q96EB6 | 2/20 | 0.40 |
| ▸ | SIRT3 | Q9NTG7 | 2/20 | 0.40 |
| ▸ | BRAF | P15056 | 1/20 | 0.40 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14534686 | 0.91 | MAPK14 (0.47) | MAPK14RAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL4417839 | 0.89 | MAPK14 (0.45) | MAPK14RAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL5496963 | 0.86 | MAPK14 (0.44) | MAPK14SMN1; SMN2MAPTPOLB | |
| SCHEMBL14534466 | 0.84 | MAPK14 (0.45) | MAPK14RAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL14534684 | 0.83 | RAB9A (0.50) | MAPK14RAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL4409868 | 0.82 | ALDH1A1 (0.47) | MAPK14RAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL14534469 | 0.82 | MAPK14 (0.43) | MAPK14RAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL5482540 | 0.81 | RAB9A (0.48) | MAPK14RAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL4565964 | 0.80 | MAPK14 (0.42) | MAPK14RAB9AKMT2ANPC1SMN1; SMN2 | |
| SCHEMBL4417851 | 0.79 | MAPK14 (0.44) | MAPK14RAB9AKMT2ANPC1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |