Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 11/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | MAPT | P10636 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | GSK3A | P49840 | 5/20 | 0.38 |
| ▸ | SRC | P12931 | 5/20 | 0.37 |
| ▸ | SYK | P43405 | 5/20 | 0.37 |
| ▸ | LCK | P06239 | 2/20 | 0.37 |
| ▸ | F10 | P00742 | 1/20 | 0.37 |
| ▸ | SCARB1 | Q8WTV0 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5490019 | 0.92 | RAB9A (0.42) | MAPK14ALDH1A1MAPTSMN1; SMN2GSK3A | |
| SCHEMBL2843245 | 0.90 | MAPK14 (0.46) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL4416963 | 0.89 | MAPK14 (0.44) | MAPK14ALDH1A1GSK3ASRCSYK | |
| SCHEMBL14534466 | 0.88 | MAPK14 (0.45) | MAPK14ALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL4416273 | 0.88 | MAPK14 (0.41) | MAPK14MAPTGSK3ASRCSYK | |
| SCHEMBL4409868 | 0.87 | ALDH1A1 (0.47) | MAPK14ALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL14534469 | 0.87 | MAPK14 (0.43) | MAPK14ALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL4408299 | 0.86 | MAPK14 (0.42) | MAPK14GSK3ASRCSYKLCK | |
| SCHEMBL4565964 | 0.85 | MAPK14 (0.42) | MAPK14ALDH1A1MAPTSMN1; SMN2HTT | |
| SCHEMBL4417785 | 0.83 | MAPK14 (0.43) | MAPK14ALDH1A1MAPTSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |