Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK14 | Q16539 | 8/20 | 0.43 |
| ▸ | SMO | Q99835 | 7/20 | 0.43 |
| ▸ | BRAF | P15056 | 2/20 | 0.42 |
| ▸ | TEK | Q02763 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.41 |
| ▸ | HTR2B | P41595 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5482540 | 0.90 | RAB9A (0.48) | MAPK14BRAFTEKMAPTSMN1; SMN2 | |
| SCHEMBL5496963 | 0.90 | MAPK14 (0.44) | MAPK14SMOPOLBMAPTSMN1; SMN2 | |
| SCHEMBL14534669 | 0.89 | MAPK14 (0.44) | MAPK14SMOPOLBMAPTSMN1; SMN2 | |
| SCHEMBL4408412 | 0.89 | MAPK14 (0.44) | MAPK14SMOPOLBMAPTSMN1; SMN2 | |
| SCHEMBL4408195 | 0.89 | PARP10 (0.48) | MAPK14SMOPOLBMAPTSMN1; SMN2 | |
| SCHEMBL4417839 | 0.87 | MAPK14 (0.45) | MAPK14BRAFTEKMAPTSMN1; SMN2 | |
| SCHEMBL4412446 | 0.86 | KDR (0.41) | BRAFTEKALOX15HSD17B10NR1H4 | |
| SCHEMBL4414872 | 0.86 | BRAF (0.49) | MAPK14BRAFTEKSMN1; SMN2NR1H4 | |
| SCHEMBL4417279 | 0.85 | MAPT (0.41) | MAPK14SMOBRAFMAPTSMN1; SMN2 | |
| SCHEMBL14534691 | 0.84 | PARP10 (0.45) | MAPK14SMOPOLBMAPTSMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |