Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | FLT1 | P17948 | 1/20 | 0.41 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | BRAF | P15056 | 7/20 | 0.40 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.40 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.38 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.38 |
| ▸ | MALT1 | Q9UDY8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5482540 | 0.87 | RAB9A (0.48) | ALOX15HSD17B10TEKBRAF | |
| SCHEMBL4410077 | 0.86 | MAPK14 (0.43) | ALOX15HSD17B10TEKBRAFNR1H4 | |
| SCHEMBL4411102 | 0.86 | MAPK14 (0.42) | KDRFLT1OPRL1MALT1 | |
| SCHEMBL4417839 | 0.84 | MAPK14 (0.45) | ALOX15HSD17B10TEKBRAF | |
| SCHEMBL4414872 | 0.83 | BRAF (0.49) | TEKBRAFNR1H4CYP2C9 | |
| SCHEMBL4408299 | 0.79 | MAPK14 (0.42) | — | |
| SCHEMBL4565711 | 0.77 | TEK (0.41) | TEKBRAFNR1H4 | |
| SCHEMBL5496963 | 0.76 | MAPK14 (0.44) | — | |
| SCHEMBL4729472 | 0.76 | RAB9A (0.44) | TEKBRAFNR1H4 | |
| SCHEMBL5483879 | 0.76 | TEK (0.46) | TEKBRAFNR1H4TRPV1CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |