Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 8/20 | 0.49 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | TEK | Q02763 | 1/20 | 0.43 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.43 |
| ▸ | SIRT2 | Q8IXJ6 | 2/20 | 0.42 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 3/20 | 0.42 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5482540 | 0.88 | RAB9A (0.48) | BRAFLMNATEKSIRT2MAPK14 | |
| SCHEMBL4417839 | 0.87 | MAPK14 (0.45) | BRAFTEKSIRT2MAPK14NPC1 | |
| SCHEMBL4410077 | 0.86 | MAPK14 (0.43) | BRAFTEKNR1H4MAPK14SMN1; SMN2 | |
| SCHEMBL5483879 | 0.84 | TEK (0.46) | BRAFNR1I2TEKNR1H4CYP2C9 | |
| SCHEMBL4727623 | 0.84 | NR1I2 (0.48) | BRAFNR1I2TP53TEKMAPK14 | |
| SCHEMBL4413445 | 0.83 | LMNA (0.44) | BRAFTP53LMNAGAATSHR | |
| SCHEMBL4412446 | 0.83 | KDR (0.41) | BRAFTEKNR1H4CYP2C9 | |
| SCHEMBL4410252 | 0.83 | BRAF (0.46) | BRAFTEKCYP2C9 | |
| SCHEMBL4411284 | 0.82 | KCNQ3 (0.46) | BRAFTEKMAPK14CYP2C9 | |
| SCHEMBL5488046 | 0.81 | BRAF (0.44) | BRAFTEKNR1H4CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |