Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | METAP2 | P50579 | 4/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | ACACB | O00763 | 1/20 | 0.42 |
| ▸ | ACACA | Q13085 | 1/20 | 0.42 |
| ▸ | MAOB | P27338 | 3/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | AXL | P30530 | 1/20 | 0.40 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.39 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | TDO2 | P48775 | 1/20 | 0.38 |
| ▸ | JAK2 | O60674 | 1/20 | 0.38 |
| ▸ | JAK1 | P23458 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | JAK3 | P52333 | 1/20 | 0.38 |
| ▸ | MAOA | P21397 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2671673 | 0.88 | CA12 (0.50) | METAP2CYP1A2ACACBACACAMAOB | |
| SCHEMBL1722163 | 0.86 | TDO2 (0.50) | METAP2CYP1A2ACACBACACAMAOB | |
| SCHEMBL4137015 | 0.84 | METAP2 (0.45) | METAP2CYP1A2ACACBACACAMAOB | |
| SCHEMBL4407859 | 0.84 | METAP2 (0.42) | METAP2CYP1A2ACACBACACAMAOB | |
| SCHEMBL1723345 | 0.81 | HSD17B2 (0.49) | LMNAMETAP2CYP1A2SMN1; SMN2TDO2 | |
| SCHEMBL17277752 | 0.78 | NOS1 (0.43) | METAP2MAOBROCK2ROCK1JAK2 | |
| SCHEMBL24656061 | 0.73 | AXL (0.44) | METAP2CYP1A2BRD4AXLROCK2 | |
| SCHEMBL2008097 | 0.73 | IDO1 (0.56) | METAP2CYP1A2BRD4AXLTDO2 | |
| SCHEMBL29990549 | 0.73 | IDO1 (0.56) | METAP2CYP1A2BRD4AXLTDO2 | |
| SCHEMBL31411282 | 0.73 | METAP2 (0.49) | METAP2CYP1A2BRD4AXLTDO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012056372-A1 | N1/N2-LACTAM ACETYL-CoA CARBOXYLASE INHIBITORS | PFIZER INC. (US) | 2012-05-03 | — | — | WO | disclosed |