Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 13/20 | 0.69 |
| ▸ | MAPT | P10636 | 11/20 | 0.69 |
| ▸ | KMT2A | Q03164 | 10/20 | 0.69 |
| ▸ | MEN1 | O00255 | 9/20 | 0.69 |
| ▸ | POLB | P06746 | 7/20 | 0.69 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.69 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.54 |
| ▸ | GAA | P10253 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 3/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.52 |
| ▸ | BLM | P54132 | 1/20 | 0.52 |
| ▸ | KDM5A | P29375 | 1/20 | 0.51 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | RECQL | P46063 | 2/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14537664 | 0.93 | MAPT (0.68) | KDM4EMAPTKMT2AMEN1POLB | |
| SCHEMBL14536216 | 0.88 | MAPT (0.72) | KDM4EMAPTKMT2AMEN1POLB | |
| SCHEMBL13548901 | 0.86 | MAPT (0.68) | KDM4EMAPTKMT2AMEN1POLB | |
| SCHEMBL4408424 | 0.85 | MAPT (0.68) | KDM4EMAPTKMT2AMEN1POLB | |
| SCHEMBL8239298 | 0.80 | KMT2A (0.60) | KDM4EMAPTKMT2AMEN1POLB | |
| SCHEMBL4404072 | 0.79 | MAPT (0.70) | KDM4EMAPTKMT2AMEN1POLB | |
| SCHEMBL13550625 | 0.76 | KDM5A (0.49) | KDM4EMAPTKMT2AMEN1POLB | |
| SCHEMBL13548879 | 0.73 | KDM5A (0.74) | KDM4EMAPTKMT2AMEN1POLB | |
| SCHEMBL12113861 | 0.72 | GAA (0.87) | KDM4EMAPTKMT2AMEN1POLB | |
| SCHEMBL8241062 | 0.72 | MAPT (0.56) | KDM4EMAPTKMT2AMEN1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 53 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11839617-B2 | Theramutein modulators | HMI Medical Innovations, LLC (US) | 2023-12-12 | — | — | US | disclosed |
| US-11839617-B2 | Theramutein modulators | HMI Medical Innovations, LLC (US) | 2023-12-12 | — | — | US | disclosed |
| US-11714080-B2 | Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC (US) | 2023-08-01 | — | — | US | disclosed |
| US-11692998-B2 | Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC (US) | 2023-07-04 | — | — | US | disclosed |
| US-11692998-B2 | Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC (US) | 2023-07-04 | — | — | US | disclosed |
| US-20210215670-A1 | COMPOUNDS AND METHODS OF IDENTIFYING, SYNTHESIZING, OPTIMIZING AND PROFILING PROTEIN MODULATORS | HMI Medical Innovations, LLC | 2021-07-15 | — | — | US | disclosed |
| US-20210215671-A1 | COMPOUNDS AND METHODS OF IDENTIFYING, SYNTHESIZING, OPTIMIZING AND PROFILING PROTEIN MODULATORS | HMI Medical Innovations, LLC | 2021-07-15 | — | — | US | disclosed |
| US-10955408-B2 | Compounds and methods of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC (US) | 2021-03-23 | — | — | US | disclosed |
| US-20210015825-A1 | THERAMUTEIN MODULATORS | HMI Medical Innovations, LLC | 2021-01-21 | — | — | US | disclosed |
| US-20210008077-A1 | THERAMUTEIN MODULATORS | HMI Medical Innovations, LLC | 2021-01-14 | — | — | US | disclosed |
| US-20100016298-A1 | Theramutein modulators | HOUSEY GERAD M | 2010-01-21 | — | — | US | disclosed |
| US-20100016298-A1 | Theramutein modulators | HOUSEY GERAD M | 2010-01-21 | — | — | US | disclosed |
| US-20090275070-A1 | Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators | HOUSEY GERARD M | 2009-11-05 | — | — | US | disclosed |
| US-20090275070-A1 | Compounds and Methods of Identifying, Synthesizing, Optimizing and Profiling Protein Modulators | HOUSEY GERARD M | 2009-11-05 | — | — | US | disclosed |
| US-20080269262-A1 | Blocking or activation of endogenous proteins variations rncoded by mutated gees | HMI MEDICAL INNOVATIONS, LLC. | 2008-10-30 | — | — | US | disclosed |
| US-20080269262-A1 | Blocking or activation of endogenous proteins variations rncoded by mutated gees | HMI MEDICAL INNOVATIONS, LLC. | 2008-10-30 | — | — | US | disclosed |
| WO-2008091681-A2 | THERAMUTEIN MODULATORS | HOUSEY GERARD M (US) | 2008-07-31 | — | — | WO | disclosed |
| US-20070111199-A1 | Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC | 2007-05-17 | — | — | US | disclosed |
| US-20070111199-A1 | Compounds and method of identifying, synthesizing, optimizing and profiling protein modulators | HMI Medical Innovations, LLC | 2007-05-17 | — | — | US | disclosed |
| WO-2007037898-A2 | THERAMUTEIN MODULATORS | HOUSEY PHARMACEUTICALS INC (US) | 2007-04-05 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210008077-A1 | THERAMUTEIN MODULATORS | TSG101, SERPINE1, PLAUR | KDM4E 4221/4885MAPT 2984/4885KMT2A 3567/4885 |
| US-20100016298-A1 | Theramutein modulators | TSG101, SERPINE1, PLAUR | KDM4E 4221/4885MAPT 2984/4885KMT2A 3567/4885 |
| US-20210015825-A1 | THERAMUTEIN MODULATORS | TSG101, SERPINE1, PLAUR | KDM4E 4221/4885MAPT 2984/4885KMT2A 3567/4885 |
| US-11839617-B2 | Theramutein modulators | TSG101, SERPINE1, PLAUR | KDM4E 4221/4885MAPT 2984/4885KMT2A 3567/4885 |
| US-20080269262-A1 | Blocking or activation of endogenous proteins variations rncoded by mutated gees | SERBP1, SERPINA6, UBE2V1 | KDM4E 4172/4885MAPT 4644/4885KMT2A 4448/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.