Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 7/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | ACHE | P22303 | 2/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 4/20 | 0.36 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.36 |
| ▸ | S1PR4 | O95977 | 2/20 | 0.36 |
| ▸ | FBP1 | P09467 | 1/20 | 0.34 |
| ▸ | RECQL | P46063 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6193016 | 0.81 | TSHR (0.47) | TSHRCYP3A4ACHEALDH1A1TDP1 | |
| SCHEMBL5631988 | 0.80 | HPRT1 (0.47) | TSHRCYP3A4ACHEHSD17B10ALDH1A1 | |
| SCHEMBL20482590 | 0.78 | TSHR (0.39) | TSHRCYP3A4ACHEHSD17B10TDP1 | |
| SCHEMBL26325 | 0.77 | TSHR (0.48) | TSHRCYP3A4ACHEHSD17B10ALDH1A1 | |
| SCHEMBL387257 | 0.75 | ALDH1A1 (0.44) | TSHRHSD17B10ALDH1A1TDP1FBP1 | |
| SCHEMBL590426 | 0.75 | TDP1 (0.44) | TSHRALDH1A1TDP1FBP1LMNA | |
| SCHEMBL6257261 | 0.75 | SNCA (0.33) | TSHRLMNA | |
| SCHEMBL2131010 | 0.75 | S100A4 (0.34) | TSHRCYP3A4ALDH1A1TDP1S1PR4 | |
| SCHEMBL3044183 | 0.75 | ALDH1A1 (0.44) | TSHRCYP3A4HSD17B10ALDH1A1GPR35 | |
| Water SCHEMBL28995322 | 0.75 | TSHR (0.46) | TSHRCYP3A4ACHEHSD17B10ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 265 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024118810-A1 | CYCLIC PYRAZOLE DIAMIDE IRE1/XBP1S ACTIVATORS | PROTEGO BIOPHARMA, INC. (US) | 2024-06-06 | — | — | WO | claimed |
| CN-117466771-A | Green preparation method of alpha-aminonitrile | 山东达因海洋生物制药股份有限公司 | 2024-01-30 | — | — | CN | claimed |
| CN-110372660-B | Synthetic method of isocoumarin derivatives | 天津大学 | 2022-11-22 | — | — | CN | claimed |
| CN-114957308-A | Quantum dot ligand, quantum dot film, QLED light-emitting device and preparation method thereof | 北京京东方技术开发有限公司 | 2022-08-30 | — | — | CN | claimed |
| CN-113105516-A | Photocleavable fluorescent labeling compounds and uses | 深圳市真迈生物科技有限公司 | 2021-07-13 | — | — | CN | claimed |
| EP-3383927-B1 | METHOD FOR IN SITU ISOMERIZATION OF POLYBUTADIENE | MICHELIN & CIE (FR) | 2020-07-29 | — | — | EP | claimed |
| EP-3206683-A1 | NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR ANESTHESIA | The Board of Trustees of the Leland Stanford Junior University (US) | 2017-08-23 | — | — | EP | claimed |
| WO-2016061538-A1 | NOVEL METHODS, COMPOUNDS, AND COMPOSITIONS FOR ANESTHESIA | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY (US) | 2016-04-21 | — | — | WO | claimed |
| CN-105418505-A | Pyrazole amides compound, preparation method therefor and application thereof | UNIV ZHEJIANG SHUREN | 2016-03-23 | — | — | CN | claimed |
| US-20140275165-A1 | COMPOUNDS THAT INHIBIT NFkB AND BACE1 ACTIVITY | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2014-09-18 | — | — | US | claimed |
| EP-0482771-A2 | Heterocyclic acids | ZENECA LIMITED (GB) | 1992-04-29 | — | — | EP | claimed |
| EP-0201203-A2 | Method of treatment of plants with aniline derivatives | MAY & BAKER LIMITED (GB) | 1986-11-12 | — | — | EP | claimed |
| EP-0181000-A2 | Foamable polyetherimide resin formulation | GENERAL ELECTRIC COMPANY (US) | 1986-05-14 | — | — | EP | claimed |
| US-4555567-A | FOR CHARGE TRANSFER IN ELECTROPHOTOGRAPHIC ELEMENT | RICOH CO., LTD. (JP) | 1985-11-26 | — | — | US | claimed |
| US-4543368-A | DIHYDRODIAZINONE BLOWING AGENT | GENERAL ELECTRIC COMPANY (US) | 1985-09-24 | — | — | US | claimed |
| EP-0031708-B1 | CEPHALOSPORIN DERIVATIVES, PROCESSES FOR THEIR MANUFACTURE, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND INTERMEDIATES THEREFOR | ICI PHARMA (FR) | 1984-06-13 | — | — | EP | claimed |
| EP-0031708-A2 | Cephalosporin derivatives, processes for their manufacture, pharmaceutical compositions containing them and intermediates therefor | ICI PHARMA (FR) | 1981-07-08 | — | — | EP | claimed |
| US-4213898-A | FOR POLYACRYLONITRILE | SANDOZ LTD. (CH) | 1980-07-22 | — | — | US | claimed |
| US-4158094-A | BLOWING AGENTS | GENERAL ELECTRIC COMPANY (US) | 1979-06-12 | — | — | US | claimed |
| US-3998803-A | TEXTILES | FIDELITY UNION TRUST COMPANY, EXECUTIVE TRUSTEE UNDER THE SANDOZ TRUST (US) | 1976-12-21 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140275165-A1 | COMPOUNDS THAT INHIBIT NFkB AND BACE1 ACTIVITY | NFKBIA, BACE1, BACE2 | TSHR 4846/4885CYP3A4 3961/4885ACHE 65/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.