Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 15/20 | 0.35 |
| ▸ | RAF1 | P04049 | 11/20 | 0.34 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.34 |
| ▸ | BTK | Q06187 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410205 | 0.89 | FASN (0.39) | BRAFRAF1CYP2C9 | |
| SCHEMBL5484353 | 0.81 | RAF1 (0.48) | BRAFRAF1 | |
| SCHEMBL4565880 | 0.78 | MAPK14 (0.44) | BRAFRAF1 | |
| SCHEMBL14534456 | 0.78 | KCNQ3 (0.49) | BRAFCYP2C9BTKKMT2AHDAC3 | |
| SCHEMBL4419832 | 0.78 | HDAC3 (0.42) | BRAFRAF1BTKMEN1KMT2A | |
| SCHEMBL4415236 | 0.77 | BRAF (0.41) | BRAFCYP2C9BTK | |
| SCHEMBL14534459 | 0.76 | BRAF (0.45) | BRAFCYP2C9HDAC3HDAC6 | |
| SCHEMBL14534461 | 0.76 | CRHR1 (0.47) | BRAFCYP2C9BTKHDAC3HDAC6 | |
| SCHEMBL4551789 | 0.73 | PDE4B (0.37) | POLB | |
| SCHEMBL4551561 | 0.73 | RAB9A (0.38) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |