Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 14/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.40 |
| ▸ | FASN | P49327 | 1/20 | 0.40 |
| ▸ | TEK | Q02763 | 1/20 | 0.40 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 1/20 | 0.37 |
| ▸ | MAPK7 | Q13164 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4410205 | 0.89 | FASN (0.39) | BRAFCYP2C9FASNTEKIRAK4 | |
| SCHEMBL4411284 | 0.84 | KCNQ3 (0.46) | BRAFCYP2C9TEKIRAK4BTK | |
| SCHEMBL4415237 | 0.81 | CRHR1 (0.44) | BRAFCYP2C9TEK | |
| SCHEMBL4414329 | 0.81 | BRAF (0.43) | BRAFCYP2C9TEKBTK | |
| SCHEMBL4414872 | 0.80 | BRAF (0.49) | BRAFCYP2C9TEKSIRT2 | |
| SCHEMBL4410252 | 0.80 | BRAF (0.46) | BRAFCYP2C9FASNTEKIRAK4 | |
| SCHEMBL5483879 | 0.79 | TEK (0.46) | BRAFCYP2C9TEK | |
| SCHEMBL5488046 | 0.78 | BRAF (0.44) | BRAFCYP2C9TEK | |
| SCHEMBL4410203 | 0.77 | HCAR3 (0.44) | BRAFCYP2C9TEKIRAK4 | |
| SCHEMBL4411197 | 0.77 | BRAF (0.35) | BRAFCYP2C9BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007056016-A2 | BISAMIDE CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-05-18 | — | — | WO | disclosed |