Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | KIT | P10721 | 1/20 | 0.41 |
| ▸ | ATR | Q13535 | 2/20 | 0.41 |
| ▸ | NAMPT | P43490 | 1/20 | 0.40 |
| ▸ | LCK | P06239 | 1/20 | 0.40 |
| ▸ | KDR | P35968 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.40 |
| ▸ | BRD4 | O60885 | 1/20 | 0.40 |
| ▸ | RAF1 | P04049 | 7/20 | 0.39 |
| ▸ | BRAF | P15056 | 7/20 | 0.39 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.38 |
| ▸ | BTK | Q06187 | 1/20 | 0.38 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14534456 | 0.81 | KCNQ3 (0.49) | HDAC3HDAC6KITLCKKDR | |
| SCHEMBL14534679 | 0.79 | KCNQ3 (0.43) | LCKMAPK14RAF1BRAFBTK | |
| SCHEMBL4411197 | 0.78 | BRAF (0.35) | HDAC3HDAC6RAF1BRAFMEN1 | |
| SCHEMBL4414329 | 0.77 | BRAF (0.43) | RAF1BRAFBTK | |
| SCHEMBL4729206 | 0.77 | RAF1 (0.47) | MAPK14RAF1BRAF | |
| SCHEMBL14534461 | 0.77 | CRHR1 (0.47) | HDAC3HDAC6KITMAPK14BRAF | |
| SCHEMBL14534459 | 0.75 | BRAF (0.45) | HDAC3HDAC6LMNAMAPTKIT | |
| SCHEMBL4727373 | 0.74 | RAF1 (0.47) | MAPK14RAF1BRAFRXFP1 | |
| SCHEMBL5496963 | 0.74 | MAPK14 (0.44) | MAPTMAPK14 | |
| SCHEMBL4413435 | 0.73 | MAPK14 (0.47) | LMNAMAPTNAMPTMAPK14BRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |