Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1B | P49286 | 5/20 | 0.66 |
| ▸ | GRIN2C | Q14957 | 3/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.58 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.58 |
| ▸ | BCHE | P06276 | 1/20 | 0.50 |
| ▸ | ACHE | P22303 | 1/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.45 |
| ▸ | HCRTR1 | O43613 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Dimethylamine SCHEMBL9024883 | 0.83 | CYP3A4 (0.56) | MTNR1BCYP3A4CYP2D6CYP2C19BCHE | |
| SCHEMBL151344 | 0.80 | CYP3A4 (0.51) | MTNR1BGRIN2CCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL145909 | 0.77 | MTNR1B (0.50) | MTNR1BGRIN2CCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL6545035 | 0.77 | CYP3A4 (0.48) | MTNR1BCYP3A4CYP2D6CYP2C19BCHE | |
| SCHEMBL16627051 | 0.77 | MTNR1B (0.61) | MTNR1BCYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL16627050 | 0.76 | MTNR1B (0.60) | MTNR1BCYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL147825 | 0.74 | CYP3A4 (0.45) | MTNR1BGRIN2CCYP3A4CYP2D6CYP2C19 | |
| SCHEMBL7899470 | 0.74 | GRIN2C (1.00) | GRIN2C | |
| SCHEMBL13064945 | 0.74 | LMNA (0.68) | MTNR1BCYP3A4CYP2D6CYP2C19MEN1 | |
| SCHEMBL4414665 | 0.74 | GRIN2C (0.64) | MTNR1BGRIN2CMEN1KMT2AGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1663983-B1 | N-SUBSTITUTED, 6,8-DIALKOXY-1,2,3,4-TETRAHYDRO-1H-ISOQUINOLINE AS POTASSIUM CHANNELS MODULATORS | 4SC AG (DE) | 2009-01-21 | — | — | EP | disclosed |
| US-20050070570-A1 | Novel potassium channels modulators | 4SC AG (DE) | 2005-03-31 | — | — | US | disclosed |
| EP-1489071-A1 | N-substituted, 3,4-dihydro-1H-isoquinoline as potassium channels modulators | 4SC AG (DE) | 2004-12-22 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070570-A1 | Novel potassium channels modulators | HCN4, KCNA4, KCNN4 | MTNR1B 569/4885GRIN2C 567/4885CYP3A4 172/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.