SCHEMBL4412405

SCHEMBL4412405

CCCCC1(C)C(=O)NN(c2ccccc2)C1=O

nearest known ligand 0.50

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 4/20 0.50
KDM4E B2RXH2 3/20 0.50
MEN1 O00255 2/20 0.50
KMT2A Q03164 2/20 0.50
ALOX12 P18054 1/20 0.50
PKM P14618 1/20 0.50
ELANE P08246 3/20 0.49
SMN1; SMN2 Q16637 5/20 0.44
LMNA P02545 3/20 0.44
HTT P42858 2/20 0.44
ALDH1A1 P00352 4/20 0.44
MAPT P10636 2/20 0.44
CNR1 P21554 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
GPR55 Q9Y2T6 1/20 0.42
CYP2C19 P33261 1/20 0.41
MMP2 P08253 3/20 0.38
MMP9 P14780 3/20 0.38
MMP3 P08254 1/20 0.38
MMP8 P22894 2/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL68540 0.81 MMP2 (0.54) GAAKDM4EMEN1KMT2AALOX12
SCHEMBL265915 0.74 GAA (0.41) GAAKDM4EMEN1KMT2AALOX12
SCHEMBL267675 0.73 ELANE (0.56) GAAKDM4EMEN1KMT2AALOX12
SCHEMBL8597730 0.73 MMP2 (0.48) GAAKDM4EMEN1KMT2AALOX12
SCHEMBL4043979 0.72 ELANE (0.40) GAAKDM4EMEN1KMT2AALOX12
SCHEMBL12997852 0.70 CYP2C19 (0.71) GAAKDM4EMEN1KMT2AALOX12
SCHEMBL4731087 0.69 KDM4E (0.77) GAAKDM4EMEN1KMT2AALOX12
SCHEMBL9751918 0.69 KDM4E (0.63) GAAKDM4EMEN1KMT2AALOX12
SCHEMBL5956271 0.69 KDM4E (0.68) GAAKDM4EMEN1KMT2AALOX12
SCHEMBL3633588 0.67 KMT2A (0.37) GAAKDM4EMEN1KMT2AALOX12

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1572157-B1 FORMULATION FOR FAST DISSOLUTION OF LIPOPHILIC COMPOUNDS UNIV GRONINGEN (NL) 2009-05-06 EP claimed
US-20050266088-A1 Formulation for fast dissolution of lipophilic compounds RIJKSUNIVERSITEIT GRONINGEN (NL) 2005-12-01 US claimed
EP-1572157-A1 FORMULATION FOR FAST DISSOLUTION OF LIPOPHILIC COMPOUNDS Rijksuniversiteit Groningen (NL) 2005-09-14 EP claimed
WO-2004054546-A1 FORMULATION FOR FAST DISSOLUTION OF LIPOPHILIC COMPOUNDS RIJKSUNIVERSITEIT GRONINGEN (NL) 2004-07-01 WO claimed
EP-1428526-A1 Formulation for fast dissolution of lipophilic compounds Rijksuniversiteit Groningen (NL) 2004-06-16 EP claimed
EP-1572157-B1 FORMULATION FOR FAST DISSOLUTION OF LIPOPHILIC COMPOUNDS UNIV GRONINGEN (NL) 2009-05-06 EP disclosed
US-20050266088-A1 Formulation for fast dissolution of lipophilic compounds RIJKSUNIVERSITEIT GRONINGEN (NL) 2005-12-01 US disclosed
EP-1572157-A1 FORMULATION FOR FAST DISSOLUTION OF LIPOPHILIC COMPOUNDS Rijksuniversiteit Groningen (NL) 2005-09-14 EP disclosed
WO-2004054546-A1 FORMULATION FOR FAST DISSOLUTION OF LIPOPHILIC COMPOUNDS RIJKSUNIVERSITEIT GRONINGEN (NL) 2004-07-01 WO disclosed
EP-1428526-A1 Formulation for fast dissolution of lipophilic compounds Rijksuniversiteit Groningen (NL) 2004-06-16 EP disclosed