SCHEMBL265915

SCHEMBL265915

CC1(C)C(=O)NN(c2ccccc2)C1=O

nearest known ligand 0.41

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
GAA P10253 7/20 0.41
ALOX12 P18054 2/20 0.41
LMNA P02545 1/20 0.41
PGR P06401 1/20 0.41
KDM4E B2RXH2 1/20 0.41
GFER P55789 1/20 0.41
ELANE P08246 3/20 0.40
MEN1 O00255 3/20 0.39
KMT2A Q03164 3/20 0.39
ALDH1A1 P00352 1/20 0.38
CYP1A2 P05177 1/20 0.38
CYP3A4 P08684 1/20 0.38
MAPT P10636 1/20 0.38
CYP2C9 P11712 1/20 0.38
CYP2C19 P33261 1/20 0.38
PDK2 Q15119 1/20 0.37
PDK4 Q16654 1/20 0.37
MMP2 P08253 1/20 0.37
MMP9 P14780 1/20 0.37
G6PD P11413 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL267675 0.77 ELANE (0.56) GAAALOX12LMNAKDM4EELANE
SCHEMBL28822554 0.75 GAA (0.51) GAAALOX12LMNAPGRKDM4E
SCHEMBL4412405 0.74 GAA (0.50) GAAALOX12LMNAKDM4EELANE
SCHEMBL68540 0.70 MMP2 (0.54) GAAALOX12LMNAKDM4EELANE
SCHEMBL2051340 0.69 PGR (0.39) GAAALOX12LMNAPGRELANE
SCHEMBL10948887 0.69 ELANE (0.63) GAAPGRELANEALDH1A1
SCHEMBL29332297 0.69 ELANE (0.50) LMNAPGRKDM4EELANEMEN1
SCHEMBL11654508 0.65 PGR (0.58) GAAPGRELANEALDH1A1
SCHEMBL1461676 0.65 AR (0.47) GAAELANEALDH1A1CYP1A2CYP2C9
SCHEMBL6487385 0.65 GAA (0.37) GAAALOX12KDM4EGFERELANE

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1655070-B1 OXIDATION CATALYST ASAHI KASEI CHEMICALS CORP (JP) 2015-07-15 EP disclosed
US-8133834-B2 Oxidation catalyst ASAHI KASEI CHEMICALS CORPORATION (JP) 2012-03-13 US disclosed
US-20100069670-A1 Oxidation catalyst ASAHI KASEI CHEMICALS CORPORATION (JP) 2010-03-18 US disclosed
US-20060229471-A1 Oxidation catalyst ASAHI KASEI CHEMICALS CORPORATION (JP) 2006-10-12 US disclosed
EP-1655070-A1 OXIDATION CATALYST Asahi Kasei Chemicals Corporation (JP) 2006-05-10 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100069670-A1 Oxidation catalyst PPOX, SOD1, HAO2 GAA 2093/4885ALOX12 208/4885LMNA 4861/4885
US-20060229471-A1 Oxidation catalyst PPOX, SOD1, HAO2 GAA 2093/4885ALOX12 208/4885LMNA 4861/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.