Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | AURKA | O14965 | 1/20 | 0.40 |
| ▸ | MARK3 | P27448 | 1/20 | 0.40 |
| ▸ | MARK4 | Q96L34 | 1/20 | 0.40 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.40 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
| ▸ | HTR3E | A5X5Y0 | 4/20 | 0.39 |
| ▸ | HTR3B | O95264 | 4/20 | 0.39 |
| ▸ | HTR3A | P46098 | 4/20 | 0.39 |
| ▸ | HTR3D | Q70Z44 | 4/20 | 0.39 |
| ▸ | HTR3C | Q8WXA8 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | NLN | Q9BYT8 | 1/20 | 0.37 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4413555 | 0.88 | BRAF (0.38) | TBK1 | |
| SCHEMBL4410708 | 0.87 | MARK3 (0.44) | AURKAMARK3MARK4TBK1 | |
| SCHEMBL4414542 | 0.86 | KCNH3 (0.39) | TBK1 | |
| SCHEMBL4412920 | 0.86 | MAPK10 (0.36) | TBK1 | |
| SCHEMBL4415084 | 0.86 | MAPK10 (0.36) | TBK1 | |
| SCHEMBL4411774 | 0.86 | MAPK10 (0.36) | AURKAMARK3TBK1 | |
| SCHEMBL4416830 | 0.86 | BRAF (0.44) | AURKATBK1 | |
| SCHEMBL4410707 | 0.85 | TBK1 (0.38) | TBK1 | |
| SCHEMBL4418433 | 0.85 | CDK2 (0.47) | AURKA | |
| SCHEMBL4410855 | 0.84 | CCNT1 (0.42) | TBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1615921-B1 | PYRIDO 2,3-D PYRIMIDIN-7-CARBOXYLIC ACID DERIVATIVES, THEIR MANUFACTURE AND USE AS PHARMACEUTICAL AGENTS | HOFFMANN LA ROCHE (CH) | 2009-03-18 | — | — | EP | claimed |