Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 3/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.33 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.33 |
| ▸ | APEX1 | P27695 | 1/20 | 0.33 |
| ▸ | THPO | P40225 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4254691 | 0.84 | TSHR (0.48) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL4676472 | 0.81 | TSHR (0.50) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL24594956 | 0.80 | TSHR (0.45) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL19978956 | 0.80 | TSHR (0.45) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL3683342 | 0.78 | ALDH1A1 (0.36) | ALDH1A1LMNA | |
| SCHEMBL3679206 | 0.78 | TDP1 (0.36) | TSHRTDP1 | |
| SCHEMBL21811647 | 0.78 | TSHR (0.43) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL10030163 | 0.78 | MAPT (0.46) | TSHRALDH1A1SMN1; SMN2TDP1MAPT | |
| SCHEMBL41548 | 0.78 | TSHR (0.52) | TSHRALDH1A1SMN1; SMN2TDP1L3MBTL1 | |
| SCHEMBL21811604 | 0.78 | ZDHHC7 (0.31) | TSHRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 55 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230219938-A1 | COMPOUNDS AND THEIR METHODS OF USE | PRAXIS PREC MEDICINES INC (US) | 2023-07-13 | — | — | US | disclosed |
| US-20130245286-A1 | PROCESS FOR PRODUCING WINE LACTONE | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2013-09-19 | — | — | US | disclosed |
| US-20130245287-A1 | PROCESS FOR PRODUCING WINE LACTONE | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2013-09-19 | — | — | US | disclosed |
| US-20130245286-A1 | PROCESS FOR PRODUCING WINE LACTONE | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2013-09-19 | — | — | US | disclosed |
| US-8481759-B2 | Process for producing wine lactone | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2013-07-09 | — | — | US | disclosed |
| US-8481759-B2 | Process for producing wine lactone | TAKASAGO INTERNATIONAL CORPORATION (JP) | 2013-07-09 | — | — | US | disclosed |
| US-20130030193-A1 | PROCESS FOR PRODUCING WINE LACTONE | TAKASAGO INTERNATIONAL CORPORATION | 2013-01-31 | — | — | US | disclosed |
| US-20130030193-A1 | PROCESS FOR PRODUCING WINE LACTONE | TAKASAGO INTERNATIONAL CORPORATION | 2013-01-31 | — | — | US | disclosed |
| EP-0951466-B1 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | ELAN PHARM INC (US) | 2009-01-21 | — | — | EP | disclosed |
| US-7390801-B2 | Cycloalkyl, lactam, lactone and related compounds, pharmaceutical compositions comprising same, and methods for inhibiting β-amyloid peptide release and/or its synthesis by use of such compounds | ATHENA NEUROSCIENCES, INC. (US) | 2008-06-24 | — | — | US | disclosed |
| EP-0951466-A2 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS BY USE OF SUCH COMPOUNDS | Elan Pharmaceuticals, Inc. (US) | 1999-10-27 | — | — | EP | disclosed |
| US-5965614-A | A PEPTIDE BLOCKING AGENT FOR TREATING ALZHEIMER'S DISEASE | ATHENA NEUROSCIENCES, INC. | 1999-10-12 | — | — | US | disclosed |
| EP-0944580-A2 | N-(ARYL/HETEROARYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE RELEASE AND/OR ITS SYNTHESIS | Elan Pharmaceuticals, Inc. (US) | 1999-09-29 | — | — | EP | disclosed |
| WO-1998028268-A2 | CYCLOALKYL, LACTAM, LACTONE AND RELATED COMPOUNDS AS β-AMYLOID PEPTIDE RELEASE INHIBITORS | ELAN PHARMACEUTICALS, INC. (US) | 1998-07-02 | — | — | WO | disclosed |
| WO-1998022441-A2 | N-(ARYL/HETEROARYL) AMINO ACID ESTERS, PHARMACEUTICAL COMPOSITIONS, AND METHODS FOR INHIBITING BETA-AMYLOID PEPTIDE AND/OR ITS SYNTHESIS | ELAN PHARMACEUTICALS, INC. (US) | 1998-05-28 | — | — | WO | disclosed |
| EP-0023785-B1 | QUINOXALINYLOXYPHENOXYALKANE CARBOXYLIC ACID DERIVATIVES, THEIR PREPARATION AND THEIR USE AS HERBICIDES | ICI AUSTRALIA LIMITED (AU) | 1985-04-03 | — | — | EP | disclosed |
| US-4353736-A | CROPS OF BARLEY, WHEAT, CORN, RICE OR COATS | CIBA-GEIGY CORPORATION (US) | 1982-10-12 | — | — | US | disclosed |
| EP-0001804-B1 | BETA-NAPHTHYL- AND BETA-TETRAHYDRONAPHTHYLPHENYL ETHERS, PROCESS FOR THEIR PREPARATION AND THEIR USE AS HERBICIDES | HOECHST AKTIENGESELLSCHAFT (DE) | 1982-05-19 | — | — | EP | disclosed |
| EP-0023785-A2 | Quinoxalinyloxyphenoxyalkane carboxylic acid derivatives, their preparation and their use as herbicides | ICI AUSTRALIA LIMITED (AU) | 1981-02-11 | — | — | EP | disclosed |
| EP-0001804-A1 | Beta-naphthyl- and beta-tetrahydronaphthylphenyl ethers, process for their preparation and their use as herbicides | HOECHST AKTIENGESELLSCHAFT (DE) | 1979-05-16 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230219938-A1 | COMPOUNDS AND THEIR METHODS OF USE | SCN1A, SCN3A, SCN1B | TSHR 3804/4885ALDH1A1 916/4885SMN1; SMN2 334/4885 |
| US-20130245286-A1 | PROCESS FOR PRODUCING WINE LACTONE | SUCLA2, ADH5, PCCA | TSHR 3352/4885ALDH1A1 360/4885SMN1; SMN2 3340/4885 |
| US-20130245287-A1 | PROCESS FOR PRODUCING WINE LACTONE | SUCLA2, ADH5, PCCA | TSHR 3352/4885ALDH1A1 360/4885SMN1; SMN2 3340/4885 |
| US-20130030193-A1 | PROCESS FOR PRODUCING WINE LACTONE | SUCLA2, ADH5, PCCA | TSHR 3352/4885ALDH1A1 360/4885SMN1; SMN2 3340/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.