Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MCL1 | Q07820 | 5/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | STAT3 | P40763 | 1/20 | 0.40 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.39 |
| ▸ | AKR1A1 | P14550 | 1/20 | 0.39 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4421324 | 0.87 | OXER1 (0.41) | MCL1ALDH1A1KMT2APOLBMEN1 | |
| SCHEMBL4414234 | 0.82 | KMT2A (0.51) | ALDH1A1KMT2APOLBPTGDR2KDM4E | |
| SCHEMBL3166032 | 0.76 | PTGDR2 (0.50) | MCL1ALDH1A1KMT2APOLBTBXAS1 | |
| SCHEMBL4415025 | 0.75 | KMT2A (0.39) | ALDH1A1KMT2AKDM4E | |
| SCHEMBL4271051 | 0.74 | L3MBTL1 (0.41) | POLBTBXAS1PTGDR2 | |
| SCHEMBL4274206 | 0.71 | HRH1 (0.36) | — | |
| SCHEMBL8021536 | 0.71 | MCL1 (0.60) | MCL1ALDH1A1KMT2ATBXAS1STAT3 | |
| SCHEMBL698228 | 0.70 | KCNA5 (0.64) | MCL1ALDH1A1KMT2ATBXAS1PTGDR2 | |
| SCHEMBL4413853 | 0.69 | CREBBP (0.49) | ALDH1A1KMT2AKDM4E | |
| SCHEMBL1520240 | 0.69 | TBXAS1 (0.64) | MCL1ALDH1A1KMT2ATBXAS1STAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |