Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.42 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.41 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | BACE1 | P56817 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414344 | 1.00 | ALDH1A1 (0.43) | ALDH1A1MTNR1AMTNR1BLMNACYP1B1 | |
| SCHEMBL4165347 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNACYP1B1TDP1L3MBTL1 | |
| SCHEMBL4165354 | 0.89 | ALDH1A1 (0.46) | ALDH1A1LMNACYP1B1TDP1L3MBTL1 | |
| SCHEMBL4186151 | 0.85 | PDE10A (0.41) | ALDH1A1LMNACYP1B1TDP1L3MBTL1 | |
| SCHEMBL4186145 | 0.85 | PDE10A (0.41) | ALDH1A1LMNACYP1B1TDP1L3MBTL1 | |
| SCHEMBL4175190 | 0.82 | NR1H3 (0.49) | ALDH1A1CYP1B1TDP1L3MBTL1NR1H3 | |
| SCHEMBL4175183 | 0.82 | NR1H3 (0.49) | ALDH1A1CYP1B1TDP1L3MBTL1NR1H3 | |
| SCHEMBL27797359 | 0.81 | MTNR1A (0.46) | MTNR1AMTNR1BCYP1B1BACE1HPGD | |
| SCHEMBL8800149 | 0.81 | MTNR1A (0.46) | MTNR1AMTNR1BCYP1B1BACE1HPGD | |
| SCHEMBL4172051 | 0.80 | NR1H3 (0.55) | ALDH1A1LMNATDP1L3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2076124-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | Acucela, Inc. (US) | 2009-07-08 | — | — | EP | disclosed |
| WO-2008131368-A2 | STYRENYL DERIVATIVE COMPOUNDS FOR TREATING OPHTHALMIC DISEASES AND DISORDERS | ACUCELA INC. (US) | 2008-10-30 | — | — | WO | disclosed |