Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR6 | P50406 | 12/20 | 0.41 |
| ▸ | BCHE | P06276 | 3/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | PPARA | Q07869 | 4/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 4/20 | 0.38 |
| ▸ | PPARD | Q03181 | 2/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4422680 | 0.85 | CNR1 (0.40) | HTR6BCHEPPARGPPARAMCL1 | |
| SCHEMBL3159492 | 0.80 | PPARG (0.61) | PPARGPPARAMCL1PPARD | |
| SCHEMBL28781865 | 0.72 | PPARG (0.40) | HTR6PPARGPPARAMCL1PPARD | |
| SCHEMBL4631786 | 0.71 | LMNA (0.54) | — | |
| SCHEMBL6747657 | 0.71 | HTR1B (0.57) | — | |
| SCHEMBL30189508 | 0.71 | HTR1B (0.57) | — | |
| SCHEMBL4416672 | 0.71 | PTGDR2 (0.47) | PPARGPPARAMCL1 | |
| SCHEMBL4425276 | 0.70 | HTR2C (0.42) | HTR6 | |
| SCHEMBL4414924 | 0.69 | PTGDR2 (0.52) | MCL1 | |
| SCHEMBL16493596 | 0.69 | NOTUM (0.37) | HTR6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2094662-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | Astellas Pharma Inc. (JP) | 2009-09-02 | — | — | EP | disclosed |
| WO-2008072784-A1 | POLYCYCLIC ACID COMPOUNDS USEFUL AS CRTH2 ANTAGONISTS AND ANTIALLERGIC AGENTS | ASTELLAS PHARMA INC. (JP) | 2008-06-19 | — | — | WO | disclosed |