Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 7/20 | 0.43 |
| ▸ | MTOR | P42345 | 5/20 | 0.43 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.43 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.43 |
| ▸ | PIK3CG | P48736 | 4/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 1/20 | 0.42 |
| ▸ | CCR4 | P51679 | 1/20 | 0.40 |
| ▸ | EGFR | P00533 | 4/20 | 0.38 |
| ▸ | KDR | P35968 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | EPHB4 | P54760 | 3/20 | 0.36 |
| ▸ | ABL1 | P00519 | 2/20 | 0.36 |
| ▸ | HCK | P08631 | 2/20 | 0.36 |
| ▸ | SRC | P12931 | 2/20 | 0.36 |
| ▸ | PRKDC | P78527 | 2/20 | 0.36 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | JAK2 | O60674 | 2/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4428827 | 0.75 | EGFR (0.50) | EGFRKDRPDGFRB | |
| SCHEMBL4411784 | 0.73 | MAPT (0.52) | MAPK1EGFRGAA | |
| SCHEMBL1307731 | 0.73 | IRAK4 (0.44) | — | |
| SCHEMBL31156717 | 0.72 | RET (0.51) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL5101385 | 0.70 | RET (0.50) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4410317 | 0.69 | TAAR1 (0.48) | MAPK1EGFRKDRABL1JAK3 | |
| SCHEMBL4414428 | 0.69 | EGFR (0.47) | MAPK1EGFRABL1 | |
| SCHEMBL4427810 | 0.69 | EGFR (0.45) | PIK3CAMTORPIK3CDPIK3CBPIK3CG | |
| SCHEMBL4412315 | 0.69 | ABCG2 (0.44) | EGFR | |
| SCHEMBL31156715 | 0.67 | RET (0.46) | PIK3CAMTORPIK3CDPIK3CBPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |