Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.52 |
| ▸ | NPC1 | O15118 | 3/20 | 0.52 |
| ▸ | RAB9A | P51151 | 3/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | TP53 | P04637 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | EGFR | P00533 | 2/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | PDE9A | O76083 | 2/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | DHFR | P00374 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 2/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412618 | 0.78 | EGFR (0.49) | MAPTNPC1RAB9ALMNAEGFR | |
| SCHEMBL4415797 | 0.78 | KDR (0.46) | EGFRDHFRKMT2A | |
| SCHEMBL4414537 | 0.73 | PIK3CA (0.43) | EGFRMAPK1GAA | |
| SCHEMBL4416584 | 0.73 | MEN1 (0.41) | MAPTEGFRALDH1A1MAPK1HTT | |
| SCHEMBL1306123 | 0.72 | ALK (0.48) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL4417806 | 0.71 | SYK (0.43) | MAPTTP53EGFRHTTSMN1; SMN2 | |
| SCHEMBL4414428 | 0.71 | EGFR (0.47) | RAB9ANPSR1EGFRMAPK1HTT | |
| SCHEMBL4414478 | 0.71 | PLAU (0.39) | MAPTEGFRL3MBTL1PDE9AKMT2A | |
| SCHEMBL11680725 | 0.70 | MAPT (0.56) | MAPTNPC1RAB9ALMNATP53 | |
| SCHEMBL4412315 | 0.68 | ABCG2 (0.44) | MAPTNPC1RAB9AEGFRALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |