Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.48 |
| ▸ | EGFR | P00533 | 4/20 | 0.45 |
| ▸ | ABL1 | P00519 | 1/20 | 0.45 |
| ▸ | ABL2 | P42684 | 1/20 | 0.45 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 1/20 | 0.42 |
| ▸ | ABCG2 | Q9UNQ0 | 2/20 | 0.41 |
| ▸ | KDR | P35968 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427810 | 0.85 | EGFR (0.45) | EGFRHTTBRAFMEN1TP53 | |
| SCHEMBL4414428 | 0.85 | EGFR (0.47) | EGFRABL1ABL2MAPK1HTT | |
| SCHEMBL4421897 | 0.83 | MAPK1 (0.39) | EGFRMAPK1HTTKDM4EMEN1 | |
| SCHEMBL4412618 | 0.81 | EGFR (0.49) | EGFRMAPK1HTTABCG2KDR | |
| SCHEMBL4412798 | 0.81 | ROCK1 (0.50) | EGFRABL1 | |
| SCHEMBL4412315 | 0.81 | ABCG2 (0.44) | EGFRABCG2RAB9AMEN1NPC1 | |
| SCHEMBL4420185 | 0.81 | ROCK1 (0.49) | EGFRMAPK1KDRROCK2CDK2 | |
| SCHEMBL4417948 | 0.80 | GAA (0.43) | TAAR1MAPK1KDRRAB9AKDM4E | |
| SCHEMBL4417806 | 0.80 | SYK (0.43) | EGFRHTTMEN1TP53TSHR | |
| SCHEMBL4414478 | 0.79 | PLAU (0.39) | EGFRMEN1TSHRKMT2ALIMK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |