Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 11/20 | 0.50 |
| ▸ | FLT1 | P17948 | 8/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 1/20 | 0.42 |
| ▸ | FLT3 | P36888 | 1/20 | 0.42 |
| ▸ | PRKCI | P41743 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 3/20 | 0.38 |
| ▸ | MAOA | P21397 | 2/20 | 0.38 |
| ▸ | SYK | P43405 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414311 | 0.82 | EGFR (0.53) | EGFRFLT1KDRMAOBMAOA | |
| SCHEMBL4421897 | 0.79 | MAPK1 (0.39) | EGFRMAPT | |
| SCHEMBL4411564 | 0.77 | CDC7 (0.49) | EGFRKDRFLT3SYKNPC1 | |
| SCHEMBL4411443 | 0.76 | SYK (0.37) | EGFRSYK | |
| SCHEMBL4417948 | 0.76 | GAA (0.43) | FLT1KDRFLT3NPC1MAPT | |
| SCHEMBL4410317 | 0.75 | TAAR1 (0.48) | EGFRKDRFLT3NPC1RAB9A | |
| SCHEMBL4414428 | 0.75 | EGFR (0.47) | EGFRRAB9A | |
| SCHEMBL4427810 | 0.75 | EGFR (0.45) | EGFRSYKMAPT | |
| SCHEMBL4414537 | 0.75 | PIK3CA (0.43) | EGFRKDRPDGFRB | |
| SCHEMBL4412315 | 0.75 | ABCG2 (0.44) | EGFRSYKNPC1MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |