Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.47 |
| ▸ | ABL1 | P00519 | 1/20 | 0.47 |
| ▸ | ABL2 | P42684 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.44 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 2/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | GFER | P55789 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | TNNI3K | Q59H18 | 1/20 | 0.39 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4427810 | 0.85 | EGFR (0.45) | EGFRHTTTSHRGFER | |
| SCHEMBL4410317 | 0.85 | TAAR1 (0.48) | EGFRABL1ABL2HTTMAPK1 | |
| SCHEMBL4412618 | 0.84 | EGFR (0.49) | EGFRHTTMAPK1RAB9ASMN1; SMN2 | |
| SCHEMBL4412315 | 0.84 | ABCG2 (0.44) | EGFRRAB9ASMN1; SMN2 | |
| SCHEMBL4417806 | 0.82 | SYK (0.43) | EGFRHTTTSHRSMN1; SMN2HSD17B10 | |
| SCHEMBL4412798 | 0.81 | ROCK1 (0.50) | EGFRABL1 | |
| SCHEMBL4414478 | 0.81 | PLAU (0.39) | EGFRTSHR | |
| SCHEMBL4420185 | 0.81 | ROCK1 (0.49) | EGFRERBB2MAPK1TNNI3KSLC2A1 | |
| SCHEMBL4417948 | 0.80 | GAA (0.43) | MAPK1RAB9AGFERSMN1; SMN2 | |
| SCHEMBL4414311 | 0.79 | EGFR (0.53) | EGFRRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |