Sugi Predict

Sugi Predict / Compounds / SCHEMBL4415023

SCHEMBL4415023

SCHEMBL4415023

O=C(Nc1ccc(N2CCOCC2)c(F)c1)C1C2CN(S(=O)(=O)c3ccc([N+](=O)[O-])cc3)CC21

nearest known ligand 0.49

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
▸ SLC6A9 P48067 2/20 0.48
▸ KMT2A Q03164 7/20 0.47
▸ MEN1 O00255 6/20 0.47
▸ ALDH1A1 P00352 4/20 0.47
▸ HPGD P15428 1/20 0.47
▸ NPSR1 Q6W5P4 1/20 0.47
▸ MAPT P10636 2/20 0.46
▸ LMNA P02545 1/20 0.46
▸ GAA P10253 1/20 0.46
▸ HTT P42858 1/20 0.45
▸ SLC6A5 Q9Y345 1/20 0.45
▸ MAPK1 P28482 1/20 0.45
▸ SMN1; SMN2 Q16637 1/20 0.45

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4417870 0.89 ALDH1A1 (0.53) KMT2AMEN1ALDH1A1HPGDNPSR1
SCHEMBL4414453 0.87 EPHX2 (0.54) KMT2AMEN1ALDH1A1HPGDNPSR1
SCHEMBL4417779 0.86 KMT2A (0.49) KMT2AMEN1ALDH1A1HPGDNPSR1
SCHEMBL4413581 0.86 RAB9A (0.53) KMT2AMEN1ALDH1A1HPGDNPSR1
SCHEMBL4425056 0.85 KMT2A (0.48) KMT2AMEN1ALDH1A1HPGDNPSR1
SCHEMBL4421514 0.85 MAPT (0.47) KMT2AMEN1ALDH1A1HPGDNPSR1
SCHEMBL4421562 0.85 ALDH1A1 (0.47) KMT2AMEN1ALDH1A1HPGDNPSR1
SCHEMBL4414283 0.84 MAPT (0.49) SLC6A9KMT2AMEN1ALDH1A1MAPT
SCHEMBL4423583 0.84 ALDH1A1 (0.49) KMT2AMEN1ALDH1A1HPGDNPSR1
SCHEMBL4415026 0.83 ALDH1A1 (0.47) SLC6A9KMT2AMEN1ALDH1A1HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1680124-B1 BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS PFIZER PROD INC (US) 2017-05-31 — — EP claimed
EP-1680124-A4 BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS PFIZER PROD INC (US) 2009-05-13 — — EP claimed
JP-2007508374-A — — 2007-04-05 — — JP claimed
EP-1680124-A2 BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS Pfizer Products Incorporated (US) 2006-07-19 — — EP claimed
US-20050096375-A1 Bicyclic [3.1.0] derivatives as glycine transporter inhibitors PFIZER INC. 2005-05-05 — — US claimed
WO-2005037216-A2 BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS PFIZER PRODUCTS INC. (US) 2005-04-28 — — WO claimed
EP-1680124-B1 BICYCLIC [3.1.0] DERIVATIVES AS GLYCINE TRANSPORTER INHIBITORS PFIZER PROD INC (US) 2017-05-31 — — EP disclosed
US-7473787-B2 Bicyclic [3.1.0] derivatives as glycine transporter inhibitors PFIZER INC (US) 2009-01-06 — — US disclosed
US-20050096375-A1 Bicyclic [3.1.0] derivatives as glycine transporter inhibitors PFIZER INC. 2005-05-05 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20050096375-A1 Bicyclic [3.1.0] derivatives as glycine transporter inhibitors SLC6A5, SLC1A5, SLC6A3 SLC6A9 9/4885KMT2A 1892/4885MEN1 4107/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.