Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM5 | P08912 | 4/20 | 0.65 |
| ▸ | ADRA1D | P25100 | 2/20 | 0.60 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.60 |
| ▸ | ADRA1B | P35368 | 2/20 | 0.60 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.57 |
| ▸ | CASP3 | P42574 | 3/20 | 0.55 |
| ▸ | CA12 | O43570 | 2/20 | 0.55 |
| ▸ | CA1 | P00915 | 2/20 | 0.55 |
| ▸ | CA9 | Q16790 | 2/20 | 0.55 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.52 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.52 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.51 |
| ▸ | MMP2 | P08253 | 1/20 | 0.50 |
| ▸ | MMP9 | P14780 | 1/20 | 0.50 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.49 |
| ▸ | PARK7 | Q99497 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11167209 | 0.87 | CASP3 (0.67) | ADRA1DADRA1AADRA1BCASP3CA12 | |
| SCHEMBL1691386 | 0.83 | CASP3 (0.68) | ADRA1DADRA1AADRA1BCASP3CA12 | |
| SCHEMBL4424799 | 0.82 | CASP3 (0.79) | ADRA1DADRA1AADRA1BCASP3CA12 | |
| SCHEMBL31752583 | 0.81 | KMT2A (0.56) | CHRM5ADRA1DADRA1AADRA1BCHRM3 | |
| SCHEMBL19835813 | 0.81 | CHRM5 (0.48) | CHRM5ADRA1DADRA1AADRA1BCHRM3 | |
| SCHEMBL13448084 | 0.81 | CA12 (0.58) | CHRM5ADRA1DADRA1AADRA1BCASP3 | |
| SCHEMBL4424839 | 0.80 | CES2 (0.61) | ADRA1DADRA1AADRA1BCASP3CA12 | |
| SCHEMBL24827438 | 0.80 | KMT2A (0.58) | CHRM5ADRA1DADRA1AADRA1BCHRM3 | |
| SCHEMBL19925305 | 0.80 | CASP3 (0.54) | CHRM5ADRA1DADRA1AADRA1BCHRM3 | |
| SCHEMBL7957008 | 0.79 | ADRA1D (0.62) | CHRM5ADRA1DADRA1AADRA1BCHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |