Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 3/20 | 0.66 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.66 |
| ▸ | HTT | P42858 | 2/20 | 0.66 |
| ▸ | AOC3 | Q16853 | 3/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | NPC1 | O15118 | 3/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | ERCC1 | P07992 | 1/20 | 0.43 |
| ▸ | ERCC4 | Q92889 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | HTR2A | P28223 | 1/20 | 0.41 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5867397 | 0.80 | MTOR (0.49) | RAB9AALDH1A1HTTAOC3NPC1 | |
| SCHEMBL9824635 | 0.80 | ALDH1A1 (1.00) | RAB9AALDH1A1HTTAOC3SMN1; SMN2 | |
| SCHEMBL3301637 | 0.78 | NPC1 (0.72) | RAB9AALDH1A1AOC3SMN1; SMN2NPC1 | |
| SCHEMBL9824160 | 0.77 | ALDH1A1 (0.70) | RAB9AALDH1A1HTTAOC3SMN1; SMN2 | |
| SCHEMBL6412640 | 0.75 | ALDH1A1 (0.68) | RAB9AALDH1A1HTTAOC3SMN1; SMN2 | |
| SCHEMBL11300231 | 0.74 | ALDH1A1 (0.66) | RAB9AALDH1A1HTTAOC3SMN1; SMN2 | |
| SCHEMBL8790300 | 0.73 | CRHBP (0.51) | RAB9AALDH1A1HTTSMN1; SMN2NPC1 | |
| SCHEMBL296937 | 0.73 | ALDH1A1 (0.64) | RAB9AALDH1A1HTTSMN1; SMN2KMT2A | |
| SCHEMBL10546564 | 0.73 | ALDH1A1 (0.51) | RAB9AALDH1A1HTTSMN1; SMN2NPC1 | |
| SCHEMBL2056269 | 0.73 | HRH3 (0.77) | RAB9AALDH1A1HTTAOC3HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| EP-1479671-A1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2004-11-24 | — | — | EP | disclosed |
| EP-1175408-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2002-01-30 | — | — | EP | disclosed |
| WO-2000066567-A1 | PYRIMIDINONE COMPOUNDS | SMITHKLINE BEECHAM PLC (GB) | 2000-11-09 | — | — | WO | disclosed |