Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | SYK | P43405 | 2/20 | 0.46 |
| ▸ | EGFR | P00533 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 1/20 | 0.44 |
| ▸ | EPHX2 | P34913 | 4/20 | 0.43 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.43 |
| ▸ | AIMP2 | Q13155 | 1/20 | 0.43 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.42 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 2/20 | 0.42 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.42 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.42 |
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | KDR | P35968 | 1/20 | 0.42 |
| ▸ | LTA4H | P09960 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4423422 | 0.81 | AXL (0.50) | LTA4H | |
| SCHEMBL12708359 | 0.79 | SRC (0.52) | SRCSYKEGFRBTKEPHX2 | |
| SCHEMBL1325549 | 0.79 | IRAK4 (0.45) | EGFRBTKEPHX2AURKARPS6KB1 | |
| SCHEMBL352581 | 0.79 | IRAK4 (0.45) | EGFRBTKEPHX2AURKARPS6KB1 | |
| SCHEMBL14578174 | 0.78 | EPHX2 (0.61) | SRCSYKEPHX2KDM4ETP53 | |
| SCHEMBL4412618 | 0.77 | EGFR (0.49) | SRCEGFRMAPK14KDR | |
| SCHEMBL4414478 | 0.74 | PLAU (0.39) | SYKEGFRTSHR | |
| SCHEMBL4411964 | 0.74 | TTBK1 (0.49) | SRCSYKEGFRAURKARPS6KB1 | |
| SCHEMBL3459161 | 0.74 | SRC (0.57) | SRCSYKEGFRBTKEPHX2 | |
| SCHEMBL3459344 | 0.74 | SRC (0.59) | SRCSYKEGFRBTKEPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |