Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.49 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.45 |
| ▸ | LMNA | P02545 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 2/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDR | P35968 | 3/20 | 0.44 |
| ▸ | DYRK3 | O43781 | 1/20 | 0.44 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | GRK5 | P34947 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | CDK7 | P50613 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417806 | 0.88 | SYK (0.43) | EGFRMEN1KMT2AMAPTROCK1 | |
| SCHEMBL4417430 | 0.88 | BRAF (0.41) | EGFRMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL4414478 | 0.87 | PLAU (0.39) | EGFRMEN1KMT2AMAPTROCK1 | |
| SCHEMBL4414428 | 0.84 | EGFR (0.47) | EGFRRAB9AHTTSMN1; SMN2MAPK1 | |
| SCHEMBL4410317 | 0.81 | TAAR1 (0.48) | EGFRMEN1KMT2ANPC1RAB9A | |
| SCHEMBL4412315 | 0.81 | ABCG2 (0.44) | EGFRMEN1KMT2AMAPTNPC1 | |
| SCHEMBL4412798 | 0.79 | ROCK1 (0.50) | EGFRROCK1 | |
| SCHEMBL4411784 | 0.78 | MAPT (0.52) | EGFRKMT2AMAPTNPC1RAB9A | |
| SCHEMBL4415797 | 0.78 | KDR (0.46) | EGFRMEN1KMT2AKDRPDGFRA | |
| SCHEMBL4420185 | 0.78 | ROCK1 (0.49) | EGFRROCK1KDRMAP4K4MAPK8 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |