Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AXL | P30530 | 11/20 | 0.50 |
| ▸ | INSR | P06213 | 3/20 | 0.50 |
| ▸ | BACE1 | P56817 | 11/20 | 0.48 |
| ▸ | LTA4H | P09960 | 1/20 | 0.45 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.45 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | HRH2 | P25021 | 1/20 | 0.45 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4416345 | 0.81 | SRC (0.48) | LTA4H | |
| SCHEMBL4414871 | 0.78 | MAPT (0.45) | — | |
| SCHEMBL351381 | 0.76 | IRAK4 (0.59) | HRH3 | |
| SCHEMBL374263 | 0.74 | LTA4H (0.52) | AXLINSRBACE1LTA4HPTGS1 | |
| SCHEMBL4411964 | 0.73 | TTBK1 (0.49) | INSR | |
| SCHEMBL12708319 | 0.72 | BACE1 (0.59) | AXLINSRBACE1HRH3 | |
| SCHEMBL2498482 | 0.71 | BACE1 (0.63) | AXLINSRBACE1LTA4HPTGS1 | |
| SCHEMBL11877770 | 0.70 | HRH3 (0.83) | LTA4HHRH2HRH3 | |
| SCHEMBL4254804 | 0.69 | AXL (0.64) | AXLBACE1LTA4HPTGS2HRH2 | |
| SCHEMBL17915915 | 0.69 | BRAF (0.56) | AXLINSRBACE1HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |