Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.49 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.49 |
| ▸ | TBK1 | Q9UHD2 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | AHR | P35869 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | PLK4 | O00444 | 4/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | KDM1A | O60341 | 1/20 | 0.42 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.41 |
| ▸ | EGFR | P00533 | 2/20 | 0.40 |
| ▸ | IGF1R | P08069 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4414871 | 0.91 | MAPT (0.45) | TTBK1TTBK2TBK1MAPTMAPK1 | |
| SCHEMBL351077 | 0.75 | SYK (0.42) | TTBK1TTBK2TBK1SYKFLT3 | |
| SCHEMBL1306157 | 0.74 | INSR (0.51) | KDRINSRAURKBIRAK4 | |
| SCHEMBL4416345 | 0.74 | SRC (0.48) | TP53SYKEGFRKDRAURKA | |
| SCHEMBL4413885 | 0.73 | FYN (0.46) | MAPTNPC1RAB9AKITFLT3 | |
| SCHEMBL4724183 | 0.72 | MAPT (0.49) | TTBK1TTBK2MAPTMAPK1TP53 | |
| SCHEMBL14547699 | 0.72 | XDH (0.54) | TTBK1TTBK2MAPTMAPK1TP53 | |
| SCHEMBL4422876 | 0.71 | PIK3CG (0.38) | NPC1RAB9AHTTEGFRCDK1 | |
| SCHEMBL4412660 | 0.71 | ALDH1A1 (0.37) | MAPTMAPK1TP53NPC1POLB | |
| SCHEMBL16423097 | 0.70 | MAPK10 (0.49) | TTBK1TTBK2MAPTMAPK1TP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |