Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAU | P00749 | 3/20 | 0.39 |
| ▸ | F2 | P00734 | 1/20 | 0.39 |
| ▸ | PLG | P00747 | 1/20 | 0.39 |
| ▸ | PLAT | P00750 | 1/20 | 0.39 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.39 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | SYK | P43405 | 1/20 | 0.39 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 3/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | PDE9A | O76083 | 1/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | LIMK2 | P53671 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4412618 | 0.87 | EGFR (0.49) | MAP4K4EGFRMEN1KMT2AMAPT | |
| SCHEMBL4417806 | 0.85 | SYK (0.43) | PLAUSYKMAP4K4EGFRMEN1 | |
| SCHEMBL4414428 | 0.81 | EGFR (0.47) | EGFRTSHR | |
| SCHEMBL4410317 | 0.79 | TAAR1 (0.48) | EGFRMEN1KMT2ATSHRLIMK1 | |
| SCHEMBL4427810 | 0.79 | EGFR (0.45) | SYKEGFRMEN1KMT2AMAPT | |
| SCHEMBL4412798 | 0.78 | ROCK1 (0.50) | EGFRROCK1 | |
| SCHEMBL4412315 | 0.78 | ABCG2 (0.44) | SYKEGFRMEN1KMT2AMAPT | |
| SCHEMBL4417430 | 0.77 | BRAF (0.41) | SYKEGFRMEN1KMT2AMAPT | |
| SCHEMBL351991 | 0.76 | ALDH1A1 (0.35) | L3MBTL1SYKPDE9ALIMK2BRD4 | |
| SCHEMBL4420185 | 0.75 | ROCK1 (0.49) | SYKMAP4K4EGFRMAPK8MAPK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7601713-B2 | Kinase inhibitors and their uses | RIGEL PHARMACEUTICALS, INC. (US) | 2009-10-13 | — | — | US | claimed |