Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 1/20 | 0.61 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PTPN7 | P35236 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | ACMSD | Q8TDX5 | 1/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | FABP4 | P15090 | 2/20 | 0.48 |
| ▸ | PPARG | P37231 | 1/20 | 0.48 |
| ▸ | PPARA | Q07869 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.47 |
| ▸ | MAOB | P27338 | 1/20 | 0.47 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL353914 | 0.85 | MAOA (0.61) | ALOX15LMNAPTPN7MAPK1ACMSD | |
| SCHEMBL5942013 | 0.83 | LMNA (0.58) | ALOX15LMNAPTPN7MAPK1MEN1 | |
| SCHEMBL3175679 | 0.83 | LMNA (0.54) | ALOX15LMNAPTPN7MAPK1ACMSD | |
| SCHEMBL3175689 | 0.83 | LMNA (0.54) | ALOX15LMNAPTPN7MAPK1ACMSD | |
| SCHEMBL413254 | 0.82 | LMNA (0.81) | ALOX15LMNAPTPN7MAPK1MEN1 | |
| SCHEMBL2769712 | 0.80 | PPARA (0.53) | ALOX15LMNAPTPN7MAPK1MEN1 | |
| SCHEMBL4683688 | 0.80 | CCNB2 (0.65) | ALOX15LMNAPTPN7MAPK1ACMSD | |
| SCHEMBL4683690 | 0.80 | CCNB2 (0.65) | ALOX15LMNAPTPN7MAPK1ACMSD | |
| SCHEMBL4683425 | 0.78 | LMNA (0.53) | ALOX15LMNAPTPN7MAPK1ACMSD | |
| SCHEMBL14143474 | 0.78 | KDM4E (0.57) | ALOX15LMNAPTPN7ACMSDKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1299354-B1 | FACTOR VIIA INHIBITORY (THIO)UREA DERIVATIVES, THEIR PREPARATION AND THEIR USE | SANOFI AVENTIS DEUTSCHLAND (DE) | 2009-07-22 | — | — | EP | disclosed |
| EP-1162194-A1 | Factor VIIa inhibitory (thio)urea derivatives, their preparation and their use | Aventis Pharma Deutschland GmbH (DE) | 2001-12-12 | — | — | EP | disclosed |