Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | PDE5A | O76074 | 1/20 | 0.40 |
| ▸ | TNF | P01375 | 1/20 | 0.39 |
| ▸ | LITAF | Q99732 | 1/20 | 0.39 |
| ▸ | G6PD | P11413 | 1/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.35 |
| ▸ | PDPK1 | O15530 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 3/20 | 0.34 |
| ▸ | ACHE | P22303 | 3/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 3/20 | 0.34 |
| ▸ | GRIN2A | Q12879 | 3/20 | 0.34 |
| ▸ | AURKA | O14965 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.33 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.33 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL436963 | 0.84 | PDE5A (0.38) | GAAPDE5ATNFLITAFG6PD | |
| SCHEMBL440869 | 0.79 | BCHE (0.46) | BCHEACHEGRIN1GRIN2AALDH1A1 | |
| SCHEMBL439580 | 0.78 | BCHE (0.40) | BCHEACHEGRIN1GRIN2AALDH1A1 | |
| SCHEMBL436008 | 0.77 | HTR1A (0.44) | G6PDALDH1A1KDM4E | |
| SCHEMBL440283 | 0.72 | DYRK1A (0.39) | GAAG6PDNPC1DYRK1APDPK1 | |
| SCHEMBL19889980 | 0.71 | SRC (0.47) | SRC | |
| SCHEMBL8709585 | 0.70 | GAA (0.48) | GAAG6PDNPC1ALDH1A1MAPT | |
| SCHEMBL441217 | 0.69 | KDM4E (0.36) | GAABCHEACHEGRIN1GRIN2A | |
| SCHEMBL4401042 | 0.69 | GAA (0.48) | GAANPC1DYRK1AALDH1A1MAPT | |
| SCHEMBL439519 | 0.69 | DYRK1A (0.39) | GAAG6PDNPC1DYRK1APDPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120065166-A1 | Bone Modulators And Methods Therewith | ESPINA VIRGINIA (US) | 2012-03-15 | — | — | US | disclosed |