Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.54 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.48 |
| ▸ | KDM1A | O60341 | 1/20 | 0.45 |
| ▸ | MAOB | P27338 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | CNR2 | P34972 | 1/20 | 0.40 |
| ▸ | METAP2 | P50579 | 1/20 | 0.39 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | MITF | O75030 | 1/20 | 0.38 |
| ▸ | KLF5 | Q13887 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16838738 | 0.89 | HSD17B10 (0.54) | HSD17B10CYP11B1KDM1AMAOBKDM4E | |
| SCHEMBL28682644 | 0.88 | CYP11B1 (0.56) | HSD17B10CYP11B1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL30747787 | 0.88 | CYP11B1 (0.56) | HSD17B10CYP11B1KDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13568531 | 0.81 | ALDH5A1 (0.54) | HSD17B10CYP11B1KDM1AKDM4EALDH1A1 | |
| SCHEMBL30578701 | 0.81 | KDM4E (0.54) | CYP11B1KDM1AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL2322298 | 0.81 | KDM4E (0.54) | CYP11B1KDM1AKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL13527931 | 0.81 | CYP11B1 (0.48) | CYP11B1KDM4EALDH1A1SMN1; SMN2NPC1 | |
| SCHEMBL4425760 | 0.81 | ALDH1A1 (0.54) | CYP11B1MAOBKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL9805366 | 0.81 | NPC1 (0.49) | CYP11B1MAOBKDM4EALDH1A1SMN1; SMN2 | |
| SCHEMBL30382878 | 0.81 | LDHA (0.52) | CYP11B1ALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019104011-A1 | CERAMIDE GALACTOSYLTRANSFERASE INHIBITORS FOR THE TREATMENT OF DISEASE | BIOMARIN PHARMACEUTICAL INC. (US) | 2019-05-31 | — | — | WO | disclosed |
| EP-1479671-B1 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2009-05-27 | — | — | EP | disclosed |
| US-7115616-B2 | Pyrimidinone compounds | SMITHKLINE BEECHAM PLC (GB) | 2006-10-03 | — | — | US | disclosed |
| US-6953803-B1 | 1-[(N-(2-(diethylamino)ethyl)-N-(4-(4-trifluoromethylphenyl)benzyl)aminocarbonylmethyl)]-2-(4-fluorobenzyl)thio-5-(1-methyl-4-pyrazolylmethyl)pyrimidin-4-one; enzyme inhibitors of lipoprotein associated phospholipase A2 (Lp-PLA2); atherosclerosis | SMITHKLINE BEECHAM P.L.C. (GB) | 2005-10-11 | — | — | US | disclosed |