Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 5/20 | 0.46 |
| ▸ | RAF1 | P04049 | 11/20 | 0.39 |
| ▸ | BRAF | P15056 | 11/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GPBAR1 | Q8TDU6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14473012 | 0.88 | ALDH1A1 (0.40) | RAF1BRAFALDH1A1SMN1; SMN2 | |
| SCHEMBL4409883 | 0.83 | MAPK14 (0.36) | RAF1BRAFALDH1A1SMN1; SMN2 | |
| SCHEMBL4417829 | 0.83 | TEK (0.45) | TEKRAF1BRAF | |
| SCHEMBL5604132 | 0.81 | TEK (0.45) | TEKRAF1BRAFALDH1A1SMN1; SMN2 | |
| SCHEMBL5593016 | 0.81 | TEK (0.53) | TEKBRAFALDH1A1SMN1; SMN2 | |
| SCHEMBL4408593 | 0.80 | TEK (0.43) | TEKRAF1BRAF | |
| SCHEMBL4419811 | 0.79 | TEK (0.46) | TEKRAF1BRAF | |
| SCHEMBL4565754 | 0.79 | RAF1 (0.51) | TEKRAF1BRAF | |
| SCHEMBL5603042 | 0.78 | TEK (0.44) | TEKRAF1BRAF | |
| SCHEMBL5593020 | 0.78 | RAB9A (0.49) | TEKRAF1BRAFALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |
| WO-2007075896-A2 | HETEROCYCLIC CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-07-05 | — | — | WO | disclosed |