Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TEK | Q02763 | 4/20 | 0.46 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.43 |
| ▸ | RAF1 | P04049 | 11/20 | 0.40 |
| ▸ | BRAF | P15056 | 11/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4417398 | 0.86 | TEK (0.54) | TEKRAF1BRAF | |
| SCHEMBL5604132 | 0.78 | TEK (0.45) | TEKMAPK14RAF1BRAF | |
| SCHEMBL4417493 | 0.78 | TEK (0.46) | TEKMAPK14BRAF | |
| SCHEMBL4725060 | 0.71 | ALDH1A1 (0.46) | TEKMAPK14RAF1BRAF | |
| SCHEMBL4410077 | 0.70 | MAPK14 (0.43) | TEKMAPK14BRAF | |
| SCHEMBL5593400 | 0.69 | RAF1 (0.46) | TEKRAF1BRAF | |
| SCHEMBL4417829 | 0.68 | TEK (0.45) | TEKRAF1BRAF | |
| SCHEMBL4419811 | 0.68 | TEK (0.46) | TEKRAF1BRAFCNR1 | |
| SCHEMBL4565827 | 0.68 | TEK (0.46) | TEKRAF1BRAF | |
| SCHEMBL4565754 | 0.68 | RAF1 (0.51) | TEKRAF1BRAFCNR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2035005-A2 | THERAPY USING CYTOKINE INHIBITORS | Kemia, INC. (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007146712-A2 | THERAPY USING CYTOKINE INHIBITORS | KEMIA, INC. (US) | 2007-12-21 | — | — | WO | disclosed |