SCHEMBL44174

SCHEMBL44174

O=C(Oc1cc(N2C(=O)C=CC2=O)cc(N2C(=O)C=CC2=O)c1N1C(=O)CCC1=O)c1ccccc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KMT2A Q03164 9/20 0.52
MAPK1 P28482 2/20 0.48
ALDH1A1 P00352 5/20 0.41
STAT3 P40763 2/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C9 P11712 1/20 0.41
CYP2C19 P33261 1/20 0.41
TLR9 Q9NR96 3/20 0.41
HSP90AA1 P07900 2/20 0.41
ATM Q13315 2/20 0.41
NPSR1 Q6W5P4 2/20 0.41
HTT P42858 2/20 0.41
MITF O75030 1/20 0.41
MAPT P10636 3/20 0.40
SMN1; SMN2 Q16637 1/20 0.40
PKM P14618 1/20 0.40
CCR6 P51684 1/20 0.40
TDP1 Q9NUW8 1/20 0.40
G6PD P11413 2/20 0.38
NSD2 O96028 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30055084 1.00 KMT2A (0.52) KMT2AMAPK1ALDH1A1STAT3CYP1A2
SCHEMBL3707631 0.74 KMT2A (0.53) KMT2AALDH1A1STAT3CYP1A2CYP2C9
SCHEMBL11382345 0.69 KMT2A (0.70) KMT2AMAPK1ALDH1A1HSP90AA1NPSR1
SCHEMBL10785394 0.67 KMT2A (0.61) KMT2AMAPK1ALDH1A1HSP90AA1NPSR1
SCHEMBL4901236 0.65 TLR9 (0.49) MAPK1ALDH1A1TLR9HSP90AA1ATM
SCHEMBL13056396 0.64 TLR9 (0.74) KMT2AMAPK1ALDH1A1TLR9HSP90AA1
SCHEMBL79589 0.64 MAPK1 (0.54) KMT2AMAPK1ALDH1A1CYP1A2CYP2C9
SCHEMBL29354362 0.64 MAPK1 (0.54) KMT2AMAPK1ALDH1A1CYP1A2CYP2C9
SCHEMBL27512460 0.64 KMT2A (0.50) KMT2AMAPK1ALDH1A1STAT3CYP1A2
SCHEMBL19381727 0.63 KMT2A (0.48) KMT2AALDH1A1STAT3CYP1A2CYP2C9

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 69 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20120141416-A1 MULTIMERIC PEPTIDE CONJUGATES AND USES THEREOF ANGIOCHEM INC. (CA) 2012-06-07 US claimed
EP-2448965-A1 MULTIMERIC PEPTIDE CONJUGATES AND USES THEREOF Angiochem Inc. (CA) 2012-05-09 EP claimed
WO-2011000095-A1 MULTIMERIC PEPTIDE CONJUGATES AND USES THEREOF ANGIOCHEM INC. (CA) 2011-01-06 WO claimed
EP-3925969-B1 PEPTIDE COMPOUNDS AND PEPTIDE CONJUGATES FOR THE TREATMENT OF CANCER THROUGH RECEPTOR-MEDIATED CHEMOTHERAPY TRANSFERT PLUS SEC (CA) 2025-09-03 EP disclosed
EP-3925969-A1 PEPTIDE COMPOUNDS AND PEPTIDE CONJUGATES FOR THE TREATMENT OF CANCER THROUGH RECEPTOR-MEDIATED CHEMOTHERAPY Transfert Plus, S.E.C. (CA) 2021-12-22 EP disclosed
EP-3380495-B1 PEPTIDE COMPOUNDS AND PEPTIDE CONJUGATES FOR THE TREATMENT OF CANCER THROUGH RECEPTOR-MEDIATED CHEMOTHERAPY TRANSFERT PLUS SEC (CA) 2021-05-19 EP disclosed
EP-2391218-B1 CONJUGATE BASED SYSTEMS FOR CONTROLLED DRUG DELIVERY SMARTCELLS INC (US) 2020-03-18 EP disclosed
US-10398781-B2 Conjugate based systems for controlled drug delivery SMARTCELLS, INC. (US) 2019-09-03 US disclosed
US-20180064824-A1 CONJUGATE BASED SYSTEMS FOR CONTROLLED DRUG DELIVERY MERCK SHARP & DOHME CORP. (US) 2018-03-08 US disclosed
US-20180015180-A1 SHORT AND D-AMINO ACID-CONTAINING POLYPEPTIDES FOR THERAPEUTIC CONJUGATES AND USES THEREOF ANGIOCHEM INC (CA) 2018-01-18 US disclosed
US-9745355-B2 Binding-site modified lectins and uses thereof SMARTCELLS, INC. (US) 2017-08-29 US disclosed
WO-2010088286-A1 SYNTHETIC CONJUGATES AND USES THEREOF SMARTCELLS, INC. (US) 2010-08-05 WO disclosed
WO-2010088276-A2 POLYNUCLEOTIDE APTAMER-BASED CROSS -LINKED MATERIALS AND USES THEREOF SMARTCELLS, INC. (US) 2010-08-05 WO disclosed
WO-2010088261-A1 BINDING-SITE MODIFIED LECTINS AND USES THEREOF SMARTCELLS, INC. (US) 2010-08-05 WO disclosed
WO-2010088294-A1 CONJUGATE BASED SYSTEMS FOR CONTROLLED DRUG DELIVERY SMARTCELLS, INC. (US) 2010-08-05 WO disclosed
WO-2010088300-A1 CRYSTALLINE INSULIN-CONJUGATES SMARTCELLS, INC. (US) 2010-08-05 WO disclosed
EP-1019721-B1 CHROMOPHORES IN THE PREPARATION OF NOVEL TANDEM CONJUGATES BECTON DICKINSON CO (US) 2007-06-13 EP disclosed
US-6372445-B1 Chromophores in the preparation of novel tandem conjugates BECTON DICKINSON AND COMPANY 2002-04-16 US disclosed
EP-1019721-A1 CHROMOPHORES IN THE PREPARATION OF NOVEL TANDEM CONJUGATES Becton Dickinson and Company (US) 2000-07-19 EP disclosed
WO-1999018437-A1 CHROMOPHORES IN THE PREPARATION OF NOVEL TANDEM CONJUGATES BECTON DICKINSON AND COMPANY (US) 1999-04-15 WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-10398781-B2 Conjugate based systems for controlled drug delivery SI, CSGALNACT1, CD44 KMT2A 3261/4885MAPK1 4735/4885ALDH1A1 705/4885
US-20120141416-A1 MULTIMERIC PEPTIDE CONJUGATES AND USES THEREOF LNPEP, DNPEP, VIP KMT2A 3839/4885MAPK1 3495/4885ALDH1A1 4126/4885
US-20180015180-A1 SHORT AND D-AMINO ACID-CONTAINING POLYPEPTIDES FOR THERAPEUTIC CONJUGATES AND USES THEREOF SLC43A1, SLC7A5, DNPEP KMT2A 2621/4885MAPK1 3098/4885ALDH1A1 2517/4885
US-20180064824-A1 CONJUGATE BASED SYSTEMS FOR CONTROLLED DRUG DELIVERY SI, CSGALNACT1, CD44 KMT2A 3261/4885MAPK1 4735/4885ALDH1A1 705/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.