Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHKA | P35790 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9070322 | 0.82 | CHKA (0.33) | CHKAUSP2SMN1; SMN2TDP1HPGD | |
| SCHEMBL3712448 | 0.81 | CHRNB2 (0.33) | — | |
| SCHEMBL28880919 | 0.68 | — | — | |
| SCHEMBL1681227 | 0.65 | TDP1 (0.33) | USP2SMN1; SMN2TDP1 | |
| SCHEMBL14964964 | 0.64 | — | — | |
| SCHEMBL28166120 | 0.64 | — | — | |
| SCHEMBL28645287 | 0.62 | — | — | |
| SCHEMBL14675777 | 0.61 | POLB (0.32) | HPGD | |
| SCHEMBL7963685 | 0.61 | NISCH (0.37) | — | |
| SCHEMBL5134286 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1696931-B1 | AMINO SUBSTITUTED DIARYL[A,D]CYCLOHEPTENE ANALOGS AS MUSCARINIC AGONISTS AND METHODS OF TREATMENT OF NEUROPSYCHIATRIC DISORDERS | ACADIA PHARM INC (US) | 2009-03-25 | — | — | EP | disclosed |