Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 2/20 | 0.32 |
| ▸ | HTT | P42858 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ether SCHEMBL1559716 | 1.00 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTLMNAPOLB | |
| Ether SCHEMBL463356 | 1.00 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL2114570 | 0.97 | ALDH1A1 (0.50) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL3966212 | 0.97 | ALDH1A1 (0.50) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL139042 | 0.97 | ALDH1A1 (0.50) | ALDH1A1TSHRHTTLMNAPOLB | |
| Dioxane SCHEMBL8034299 | 0.94 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL28266595 | 0.94 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL28163248 | 0.94 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL8982353 | 0.94 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTLMNAPOLB | |
| Tetrahydrofuran SCHEMBL10676279 | 0.94 | ALDH1A1 (0.47) | ALDH1A1TSHRHTTLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1461340-B1 | TRIOXANE DERIVATIVES AS ANTIMALARIA OR ANTICANCER COMPOUNDS | UFC LTD (GB) | 2009-04-08 | — | — | EP | disclosed |
| US-20050070595-A1 | Trioxane derivatives as antimalaria or anticancer compounds | UFC LIMITED (GB) | 2005-03-31 | — | — | US | disclosed |
| EP-1461340-A2 | TRIOXANE DERIVATIVES AS ANTIMALARIA OR ANTICANCER COMPOUNDS | UFC LIMITED (GB) | 2004-09-29 | — | — | EP | disclosed |
| WO-2003048168-A2 | TRIOXANE DERIVATIVES AS ANTIMALARIA OR ANTICANCER COMPOUNDS | UFC LIMITED (GB) | 2003-06-12 | — | — | WO | disclosed |
| US-RE38117-E1 | Trioxane dimer compound having antiproliferative and antitumor activities | HAUSER, INC. | 2003-05-06 | — | — | US | disclosed |
| EP-1021438-A4 | TRIOXANE DIMER COMPOUNDS HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES | HAUSER INC (US) | 2002-08-28 | — | — | EP | disclosed |
| EP-1021438-A1 | TRIOXANE DIMER COMPOUNDS HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES | Hauser, Inc. (US) | 2000-07-26 | — | — | EP | disclosed |
| US-6004997-A | ANTICANCER AGENTS | HAUSER, INC. (US) | 1999-12-21 | — | — | US | disclosed |
| US-5840925-A | Trioxane dimer compounds having antiproliferative and antitumor activities | HAUSER, INC. (US) | 1998-11-24 | — | — | US | disclosed |
| WO-1998024786-A9 | TRIOXANE DIMER COMPOUNDS HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES | — | 1998-10-08 | — | — | WO | disclosed |
| WO-1998024786-A1 | TRIOXANE DIMER COMPOUNDS HAVING ANTIPROLIFERATIVE AND ANTITUMOR ACTIVITIES | HAUSER, INC. (US) | 1998-06-11 | — | — | WO | disclosed |
| WO-1993014756-A1 | 1,2,4-TRIOXANE COMPOUNDS HAVING ANTIMALARIAL ACTIVITY | THE JOHNS HOPKINS UNIVERSITY (US) | 1993-08-05 | — | — | WO | disclosed |
| US-5225437-A | 1,2,4-trioxane compounds having antimalarial activity | THE JOHNS HOPKINS UNIVERSITY (US) | 1993-07-06 | — | — | US | disclosed |
| US-4221712-A | QUENCHING A SULFONATED POLYMER WITH ISOPROPANOL, NEUTRALIZATION | EXXON RESEARCH & ENGINEERING CO. (US) | 1980-09-09 | — | — | US | disclosed |
| EP-0002353-A1 | A process for forming a polymer that contains metalsulphonate | EXXON RESEARCH AND ENGINEERING COMPANY (US) | 1979-06-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050070595-A1 | Trioxane derivatives as antimalaria or anticancer compounds | PHOSPHO1, PIK3CA, PFKFB1 | ALDH1A1 4353/4885TSHR 2993/4885HTT 4392/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.