Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK1 | Q15118 | 12/20 | 0.41 |
| ▸ | PDK2 | Q15119 | 12/20 | 0.41 |
| ▸ | PDK3 | Q15120 | 12/20 | 0.41 |
| ▸ | PDK4 | Q16654 | 12/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | RAB9A | P51151 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | POLB | P06746 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | AR | P10275 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14217437 | 0.84 | L3MBTL1 (0.39) | PDK1PDK2PDK3PDK4RAB9A | |
| SCHEMBL1291381 | 0.81 | PDK1 (0.46) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL29624959 | 0.81 | PDK1 (0.46) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL4422890 | 0.80 | PDK1 (0.43) | PDK1PDK2PDK3PDK4POLB | |
| SCHEMBL2432483 | 0.80 | MEN1 (0.44) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL2430587 | 0.76 | PDK1 (0.42) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL2433013 | 0.74 | PDK1 (0.38) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL10072798 | 0.74 | CETP (0.54) | MEN1RAB9AKMT2ALMNAMAPT | |
| SCHEMBL13889771 | 0.71 | LMNA (0.46) | PDK1PDK2PDK3PDK4MEN1 | |
| SCHEMBL9835326 | 0.70 | LMNA (0.54) | PDK1PDK2PDK3PDK4MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7632858-B2 | Open chain prolyl urea-related modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-15 | — | — | US | disclosed |
| US-7632858-B2 | Open chain prolyl urea-related modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-15 | — | — | US | disclosed |
| US-7632858-B2 | Open chain prolyl urea-related modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY (US) | 2009-12-15 | — | — | US | disclosed |
| US-20080108691-A1 | OPEN-CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-08 | — | — | US | disclosed |
| US-20080108691-A1 | OPEN-CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2008-05-08 | — | — | US | disclosed |
| EP-1567487-A4 | OPEN CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION | BRISTOL MYERS SQUIBB CO (US) | 2005-11-16 | — | — | EP | disclosed |
| EP-1567487-A2 | OPEN CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION | Bristol-Myers Squibb Company (US) | 2005-08-31 | — | — | EP | disclosed |
| US-20050059652-A1 | Open chain prolyl urea-related modulators of androgen receptor function | BRISTOL-MYERS SQUIBB COMPANY | 2005-03-17 | — | — | US | disclosed |
| WO-2004045518-A2 | OPEN CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION | BRISTOL-MYERS SQUIBB COMPANY (US) | 2004-06-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20050059652-A1 | Open chain prolyl urea-related modulators of androgen receptor function | AR, SHBG, ESRRA | PDK1 1311/4885PDK2 1406/4885PDK3 1180/4885 |
| US-20080108691-A1 | OPEN-CHAIN PROLYL UREA-RELATED MODULATORS OF ANDROGEN RECEPTOR FUNCTION | SHBG, ESRRA, AR | PDK1 840/4885PDK2 1079/4885PDK3 873/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.