Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
| ▸ | GNRHR | P30968 | 12/20 | 0.32 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986121 | 0.86 | SMN1; SMN2 (0.39) | ADORA2BGNRHRMAPK14 | |
| SCHEMBL4484784 | 0.76 | SMN1; SMN2 (0.37) | ADORA2BGNRHRMAPK14 | |
| SCHEMBL3913556 | 0.73 | ALDH1A1 (0.40) | GNRHR | |
| SCHEMBL4493753 | 0.73 | CASR (0.38) | ADORA2BGNRHRMAPK14 | |
| SCHEMBL4478946 | 0.71 | MAPT (0.43) | CYP3A4 | |
| SCHEMBL3985349 | 0.71 | ALDH1A1 (0.34) | GNRHRMAPK14 | |
| SCHEMBL3986025 | 0.71 | HCRTR1 (0.37) | GNRHRMAPK14CYP3A4 | |
| SCHEMBL4483063 | 0.70 | SYK (0.36) | ADORA2BMAPK14 | |
| SCHEMBL3986451 | 0.70 | JAK2 (0.36) | ADORA2BGNRHRMAPK14 | |
| SCHEMBL4877540 | 0.70 | TSHR (0.35) | ADORA2BGNRHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2034993-A2 | PYRAZINONES AS CELLULAR PROLIFERATION INHIBITORS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-03-18 | — | — | EP | disclosed |
| WO-2007149448-A2 | PYRAZINONES AS CELLULAR PROLIFERATION INHIBITORS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-12-27 | — | — | WO | disclosed |
| EP-1848711-A1 | FUNGICIDAL PYRAZINE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089060-A1 | FUNGICIDAL PYRAZINE DERIVATIVES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2006-08-24 | — | — | WO | disclosed |