Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GNRHR | P30968 | 6/20 | 0.33 |
| ▸ | JAK2 | O60674 | 2/20 | 0.32 |
| ▸ | JAK1 | P23458 | 2/20 | 0.32 |
| ▸ | TYK2 | P29597 | 2/20 | 0.32 |
| ▸ | JAK3 | P52333 | 2/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986121 | 0.74 | SMN1; SMN2 (0.39) | TSHRALDH1A1LMNASMN1; SMN2GNRHR | |
| SCHEMBL4484784 | 0.71 | SMN1; SMN2 (0.37) | TSHRALDH1A1LMNASMN1; SMN2GNRHR | |
| SCHEMBL3986813 | 0.70 | TRAP1 (0.37) | TSHRLMNATP53SMN1; SMN2HTT | |
| SCHEMBL4486345 | 0.70 | TRAP1 (0.37) | TSHRLMNATP53SMN1; SMN2HTT | |
| SCHEMBL4418581 | 0.70 | ADORA2B (0.32) | GNRHRADORA2B | |
| SCHEMBL3913556 | 0.69 | ALDH1A1 (0.40) | TSHRALDH1A1LMNASMN1; SMN2GNRHR | |
| SCHEMBL4492304 | 0.68 | ACLY (0.31) | TSHRALDH1A1 | |
| SCHEMBL4481630 | 0.68 | ACLY (0.31) | TSHRALDH1A1 | |
| SCHEMBL3985349 | 0.67 | ALDH1A1 (0.34) | TSHRALDH1A1LMNASMN1; SMN2GNRHR | |
| SCHEMBL4489281 | 0.67 | KCNH2 (0.34) | TSHRLMNASMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | SHARPE PAULA LOUISE | 2008-08-14 | — | — | US | claimed |
| EP-1848711-A1 | FUNGICIDAL PYRAZINE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-10-31 | — | — | EP | claimed |
| WO-2006089060-A1 | FUNGICIDAL PYRAZINE DERIVATIVES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2006-08-24 | — | — | WO | claimed |
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | SHARPE PAULA LOUISE | 2008-08-14 | — | — | US | disclosed |
| EP-1848711-A1 | FUNGICIDAL PYRAZINE DERIVATIVES | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-10-31 | — | — | EP | disclosed |
| WO-2006089060-A1 | FUNGICIDAL PYRAZINE DERIVATIVES | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2006-08-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | CBR3, CBR1, NR0B1 | TSHR 795/4885ALDH1A1 2652/4885LMNA 4221/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.