Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.34 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | GNRHR | P30968 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 4/20 | 0.33 |
| ▸ | F7 | P08709 | 4/20 | 0.33 |
| ▸ | F3 | P13726 | 4/20 | 0.33 |
| ▸ | P2RX3 | P56373 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3986121 | 0.83 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2MAPK14NPSR1LMNA | |
| SCHEMBL4484784 | 0.80 | SMN1; SMN2 (0.37) | ALDH1A1SMN1; SMN2MAPK14NPSR1LMNA | |
| SCHEMBL3913556 | 0.80 | ALDH1A1 (0.40) | ALDH1A1SMN1; SMN2NPSR1LMNAPOLB | |
| SCHEMBL4493753 | 0.77 | CASR (0.38) | ALDH1A1SMN1; SMN2MAPK14NPSR1LMNA | |
| SCHEMBL3986025 | 0.75 | HCRTR1 (0.37) | ALDH1A1SMN1; SMN2MAPK14NPSR1POLB | |
| SCHEMBL4483063 | 0.74 | SYK (0.36) | ALDH1A1SMN1; SMN2MAPK14NPSR1LMNA | |
| SCHEMBL4418581 | 0.71 | ADORA2B (0.32) | MAPK14GNRHR | |
| SCHEMBL3991579 | 0.71 | SMN1; SMN2 (0.39) | ALDH1A1SMN1; SMN2MAPK14NPSR1LMNA | |
| SCHEMBL5319644 | 0.68 | TDP1 (0.36) | ALDH1A1SMN1; SMN2NPSR1LMNAGNRHR | |
| SCHEMBL4877540 | 0.67 | TSHR (0.35) | ALDH1A1SMN1; SMN2NPSR1LMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | E.I. DUPONT DE NEMOURS AND COMPANY (US) | 2009-07-23 | — | — | US | disclosed |
| EP-2034993-A2 | PYRAZINONES AS CELLULAR PROLIFERATION INHIBITORS | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 2009-03-18 | — | — | EP | disclosed |
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | SHARPE PAULA LOUISE | 2008-08-14 | — | — | US | disclosed |
| WO-2007149448-A2 | PYRAZINONES AS CELLULAR PROLIFERATION INHIBITORS | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 2007-12-27 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080194585-A1 | Fungicidal Pyrazine Derivatives | CBR3, CBR1, NR0B1 | ALDH1A1 2652/4885SMN1; SMN2 3995/4885MAPK14 2889/4885 |
| US-20090186907-A1 | Pyrazinones As Cellular Proliferation Inhibitors | MKI67, NR0B1, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | ALDH1A1 1820/4885SMN1; SMN2 3158/4885MAPK14 1574/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.